Molecule and chimeric molecules thereof
AssigneeApollo Life Sciences Limited
InventorsJohn D. Priest, Alan D. Watts, Jason S. Whittaker, Teresa A. Domagala, Carol M. Y. Lee, Nikolien S. Thomas
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AssigneeApollo Life Sciences Limited
InventorsJohn D. Priest, Alan D. Watts, Jason S. Whittaker, Teresa A. Domagala, Carol M. Y. Lee, Nikolien S. Thomas
Estimating the term…
The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule which comprises a C-type lectin or an EGF-like domain such as amphiregulin, CD209L, Langerin, L-selectin or chimeric molecules thereof comprising at least a portion of the protein molecule, such as amphiregulin-Fc, CD209L-Fc, Langerin S, Langerin L, Langerin L-FLAG, Langerin-Fc, L-selectin-Fc wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
An isolated protein comprising a profile of measurable physiochemical parameters, wherein said profile is indicative of, associated with or forms the basis of one or more distinctive pharmacological traits, wherein said isolated protein comprises a physiochemical profile comprising a number of measurable physiochemical parameters, {[Px]1, [Px]2, . . . [Px]n,}, wherein Px represents a measurable physiochemical parameter and “n” is an integer ≧1, wherein each of [Px]1 to [Px]n is a different measurable physiochemical parameter, wherein the value of any one of the measurable physiochemical characteristics or an array of values of more than one measurable physiochemical characteristics is indicative of, associated with, or forms the basis of, a distinctive pharmacological trait, Ty, or an array of distinctive physiochemical traits {[Ty]1, [Ty]2, . . . [Ty]m} wherein Ty represents a distinctive pharmacological trait and m is an integer ≧1 and each of [Ty]1 to [Ty]m is a different pharmacological trait, wherein the isolated protein is selected from the group comprising amphiregulin, CD209L-Fc, Langerin, Langerin S, Langerin L, L-selectin-Fc.
A nucleotide sequence selected from the list consisting of SEQ ID NOs:
An isolated protein or chimeric molecule encoded by a nucleotide sequence selected from the list consisting of SEQ ID NOs:
An isolated nucleic acid molecule encoding a protein or chimeric molecule or a functional part thereof comprising a sequence of nucleotides having at least 90% similarity SEQ ID NOs:
An isolated nucleic acid molecule comprising a sequence of nucleotides encoding a protein or chimeric molecule having an amino acid sequence substantially as set forth in one or more of SEQ ID NOs:
Dependencies are inferred from the claim text.