Compositions and methods for the treatment of immune related diseases
OwnerHenry Chiu, Hilary Clark +5inventors
InventorsHenry Chiu, Hilary Clark, Kathryn Dennis, Sherman Fong, Jill R. Schoenfeld, William I. Wood, Thomas D. Wu
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Abstract
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
Claims21
1-28. (canceled)
A method of diagnosing an inflammatory immune response in a mammal, said method comprising detecting the level of expression of a gene encoding a PRO38457 polypeptide of SEQ ID NO:172, (a) in a test sample of tissue cells obtained from the mammal, and (b) in a control sample of known normal tissue cells of the same cell type, wherein a differential expression of said gene in the test sample as compared to the control sample is indicative of the presence of an inflammatory immune response in the mammal from which the test tissue cells were obtained.
A method of diagnosing an immune related disease in a mammal, said method comprising detecting the level of expression of a gene encoding a PRO38457 polypeptide of SEQ ID NO:172, (a) in a test sample of tissue cells obtained from the mammal, and (b) in a control sample of known normal tissue cells of the same cell type, wherein a differential expression of said gene in the test sample as compared to the control sample is indicative of the presence of an immune related disease in the mammal from which the test tissue cells were obtained.
A method of diagnosing an immune related disease in a mammal, said method comprising determining the expression level of the PRO38457 polypeptide of SEQ ID NO:172 in test biological sample relative to a normal biological sample, wherein a differential expression of said polypeptide in the test biological sample is indicative of the presence of an inflammatory immune response in the mammal from which the test tissue cells were obtained.
A method of treating an immune related disorder in a mammal in need thereof comprising administering to said mammal a therapeutically effective amount of an antibody that binds to the PRO38457 polypeptide.
A method of stimulating the immune response in a mammal, said method comprising administering to said mammal an effective amount of the PRO38457 polypeptide, wherein said immune response is stimulated.
A method of inhibiting the immune response in a mammal, said method comprising administering to said mammal an effective amount of an antibody to the PRO38457 polypeptide, wherein said immune response is inhibited.
Dependencies are inferred from the claim text.