Methods and compositions for treatment and diagnosis of encephalitis or epilepsy
AssigneeThe Trustees of the University of Pennsylvania
InventorsJosep Dalmau, Myrna Rosenfeld, David R. Lynch
Life of this patent
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Abstract
This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of testing a biological sample of the subject for an antibody to an NR1 subunit of the NMDA receptor. This invention further provides methods of treating an autoimmune encephalitis or an epilepsy, comprising the steps of detecting an antibody to an NR1 subunit of the NMDA receptor and treating a tumor associated with the disease.
Claims24
A method of diagnosing encephalitis in a subject, comprising the steps of obtaining a biological sample from the subject;
- and testing the biological sample for an antibody to an NR1 subunit of an NMDA receptor, whereby a presence of said antibody in said biological sample indicates an autoimmune encephalitis, thereby determining a cause of an encephalitis in a subject.
6-8. (canceled)
14-20. (canceled)
A method of diagnosing epilepsy in a subject, comprising the steps of:
- obtaining a body fluid from the subject;
- and testing the body fluid for the presence of an antibody to an NR1 subunit of the NMDA receptor, whereby a presence of said antibody indicates a presence of a tumor in said subject and said tumor is a cause of said epilepsy, thereby diagnosing epilepsy in a subject.
22-23. (canceled)
A method of treating autoimmune encephalitis in a subject, comprising the steps of:
- detecting a tumor associated with an autoimmune encephalitis by testing a body fluid from the subject for an antibody to an NR1 subunit of the NMDA receptor, whereby a presence of said antibody indicates a presence of said tumor in said subject and that said tumor is a cause of said autoimmune encephalitis;
- and treating said tumor.
33-48. (canceled)
Dependencies are inferred from the claim text.