Affinity Regions
OwnerMartijn Frans Ben Gerard Gebbink, Barend Boumainventors
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Abstract
The present invention provides a method for selecting from a collection of IgIV molecules, at least one IgIV molecule comprising an affinity region that is capable of interacting with a misfolded protein and/or with an epitope of a cross-β structure and/or with an epitope of a protein comprising a cross-β structure, said method comprising contacting a collection of IgIV molecules with a misfolded protein and/or with a cross-β structure and/or with a protein comprising a cross-β structure and collecting at least one IgIV molecule comprising an affinity region interacting with said misfolded protein and/or epitope.
Claims47
A method for selecting from a collection of IgIV molecules, at least one IgIV molecule comprising an affinity region that is capable of interacting with an epitope of a misfolded protein and/or with an epitope of a cross-β structure and/or with an epitope of a protein comprising a cross-β structure, said method comprising contacting a collection of IgIV molecules with a misfolded protein, a cross-β structure and/or a protein comprising a cross-β structure and collecting at least one IgIV molecule comprising an affinity region interacting with said epitope.
A collection of IgIV molecules, enriched in IgIV molecules comprising an affinity region that is capable of interacting with an epitope of a misfolded protein, a cross-β structure and/or with an epitope of a protein comprising a cross-β structure.
A composition comprising at least 5 isolated, synthetic and/or recombinant molecules comprising an affinity region that is capable of interacting with an epitope of a misfolded protein, a cross-β structure and/or with an epitope of a protein comprising a cross-β structure.
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Dependencies are inferred from the claim text.