Antibodies to MT-SP1 serine protease
AssigneeThe Regents of the University of California
InventorsCharles S. Craik, Toshihiko Takeuchi, Marc Shuman
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Abstract
This invention provides a novel membrane-type serine protease (designated MT-SP1) elevated expression of which is associated with cancer. In one embodiment, this invention provides a method obtaining a prognosis or of detecting or staging a cancer in an organism. The method involves providing a biological sample from the organism and detecting the level of a membrane type serine protease 1 (MT-SP1) in the sample, where an elevated level of the membrane-type serine protease, as compared to the level of the protease in a biological sample from a normal healthy organism indicates the presence or stage of the cancer.
Claims23
1-80. (canceled)
An isolated antibody that specifically binds to an MT-SP1 proteinase domain that is at least 95% identical to the amino acid sequence from residue 615 to 855 shown in SEQ ID NO. 2.
Dependencies are inferred from the claim text.