Methods of Using Death Receptor Agonists and EGFR Inhibitors
OwnerAvi J. Ashkenaziinventor
Life of this patent
Estimating the term…
Abstract
Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and EGFR inhibitors to treat pathological conditions such as cancer are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with EGFR inhibitors, such as Tarceva™.
Claims38
A method of enhancing apoptosis in one or more mammalian cells, comprising exposing said cells to an effective amount of death receptor agonist and EGFR inhibitor.
A method of treating a proliferative disorder in a mammal comprising administering to said mammal Apo2L/TRAIL and an EGFR inhibitor.
A method of treating cancer cells, comprising exposing mammalian cancer cells to a synergistic effective amount of death receptor agonist and EGFR inhibitor.
Dependencies are inferred from the claim text.