Prophylactic/therapeutic agent for cancer
AssigneesJapanese Foundation for Cancer Research, Takeda Pharmaceutical Company Limited
InventorsTetsuo Mashima, Takashi Tsuruo
Life of this patent
Estimating the term…
Abstract
A compound or its salt that inhibits the activity of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1; a compound or its salt that inhibits the expression of a gene for the protein; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or a part of the nucleotide sequence; an antibody against the protein; etc. are useful as preventive/therapeutic agents for cancer, apoptosis promoters for cancer cells, or the like.
Claims71
A preventive/therapeutic agent for cancer comprising a compound or a salt thereof which inhibits the activity of an enzyme belonging to the acyl-CoA synthetase family.
A preventive/therapeutic agent for cancer comprising a compound or a salt thereof which inhibits the gene expression of an enzyme belonging to the acyl-CoA synthetase family.
A preventive/therapeutic agent for cancer, which comprises 1-hydroxy-3-undeca-2,4,7-triene-1-ylidentriaz-1-ene.
An antisense polynucleotide comprising an entire or part of a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A siRNA or shRNA to a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A preventive/therapeutic agent for cancer comprising an antibody against an enzyme belonging to the acyl-CoA synthetase family.
A diagnostic agent for cancer comprising an antibody against an enzyme belonging to the acyl-CoA synthetase family.
A diagnostic agent for cancer comprising a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A method for diagnosis of cancer, which comprises using an antibody against an enzyme belonging to the acyl-CoA synthetase family or a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
Use of an enzyme belonging to the acyl-CoA synthetase family as a diagnostic marker of cancer.
A screening method of a medicament for preventing/treating cancer, which comprises using an enzyme belonging to the acyl-CoA synthetase family.
A screening kit for a medicament for preventing/treating cancer, which comprises an enzyme belonging to the acyl-CoA synthetase family.
A screening method for a medicament for preventing/treating cancer, which comprises using a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A screening kit for a medicament for preventing/treating cancer, which comprises a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A screening method of a medicament for preventing/treating cancer, which comprises measuring the amount or activity of an enzyme belonging to the acyl-CoA synthetase family.
A method for preventing/treating cancer, which comprises inhibiting the activity of an enzyme belonging to the acyl-CoA synthetase family.
A method for preventing/treating cancer, which comprises inhibiting the gene expression of an enzyme belonging to the acyl-CoA synthetase family.
A method for preventing/treating cancer, which comprises administering to a mammal an effective dose of (i) a compound or a salt thereof which inhibits the activity of an enzyme belonging to the acyl-CoA synthetase family, (ii) a compound or a salt thereof which inhibits the gene expression of an enzyme belonging to the acyl-CoA synthetase family, (iii) an antibody against an enzyme belonging to the acyl-CoA synthetase family, or (iv) an antisense polynucleotide comprising an entire or part of a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
(canceled)
An agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, comprising a compound or a salt thereof which inhibits the activity of an enzyme belonging to the acyl-CoA synthetase family.
An agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises a compound or a salt thereof which inhibits the gene expression of an enzyme belonging to the acyl-CoA synthetase family.
An agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises 1-hydroxy-3-undeca-2,4,7-triene-1-ylidenetriaz-1-ene.
An agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises an antibody against an enzyme belonging to the acyl-CoA synthetase family.
A screening method of an agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises using an enzyme belonging to the acyl-CoA synthetase family.
A screening kit for an agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises an enzyme belonging to the acyl-CoA synthetase family.
A screening method of an agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises using a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
A screening kit for a medicament for preventing/treating cancer, which comprises polynucleotide encoding enzyme belonging to the acyl-CoA synthetase family.
A screening method of an agent for promoting the apoptosis of cancer cells or an agent for suppressing the growth of cancer cells, which comprises measuring the amount or activity of an enzyme belonging to the acyl-CoA synthetase family.
A method for promoting the apoptosis of cancer cells or suppressing the growth of cancer cells, which comprises inhibiting the activity of an enzyme belonging to the acyl-CoA synthetase family.
A method for promoting the apoptosis of cancer cells or suppressing the growth of cancer cells, which comprises inhibiting the gene expression of an enzyme belonging to the acyl-CoA synthetase family.
A method for promoting the apoptosis of cancer cells or suppressing the growth of cancer cells, which comprises administering to a mammal an effective dose of (i) a compound or a salt thereof which inhibits the activity of an enzyme belonging to the acyl-CoA synthetase family, (ii) a compound or a salt thereof which inhibits the gene expression of an enzyme belonging to the acyl-CoA synthetase family, (iii) an antibody against an enzyme belonging to the acyl-CoA synthetase family, or (iv) an antisense polynucleotide comprising an entire or part of a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding an enzyme belonging to the acyl-CoA synthetase family.
(canceled)
An anticancer drug resistance improving agent comprising a compound or a salt thereof which inhibits the activity of an enzyme belonging to the acyl-CoA synthetase family.
A method of improving anticancer drug resistance, which comprises inhibiting the activity of an enzyme belonging to the acyl-CoA synthetase family.
A screening method of a medicament for improving anticancer drug resistance, which comprises using an enzyme belonging to the acyl-CoA synthetase family.
Use of an enzyme belonging to the acyl-CoA synthetase family as a diagnostic marker of anticancer drug sensitivity.
Dependencies are inferred from the claim text.