Dichloroacetate in combination with clinically high levels of cardioprotective or hemodynamic drugs
AssigneeThe Governors of the University of Alberta TEC Edmonton
InventorsGARY D. LOPASCHUK, Ruth L. Collins-Nakai
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Abstract
The present invention provides compositions and methods for using cardioprotective or hemodynamic drugs in combination with dichloroacetate enabling usage of cardioprotective or hemodynamic drugs at concentrations higher than used in normal clinical practice without increasing deleterious side effects normally associated with the cardioprotective or hemodynamic drug, thereby conferring added clinical benefit. The present invention teaches administration of DCA with cardioprotective or hemodynamic drugs as an adjunct therapy thereby conferring added clinical benefit to clinically recommended protocols.
Claims45
A composition comprising a unit dosage form of dichloroacetate (DCA) and a cardioprotective or hemodynamic drug, wherein DCA is present in an amount sufficient to ameliorate the negative side effects of the drug when administered to a subject experiencing or recovering from an ischemic event, wherein the at least one negative side effect is selected from an effect on glucose oxidation, glycolysis, heart rate, peak systolic pressure, cardiac output, oxygen consumption, coronary flow, fatty acid oxidation, cardiac efficiency, aortic outflow, cardiac work, and heart rate×peak systolic pressure (HR×PSP).
33-88. (canceled)
A composition comprising a unit dosage form of dichloroacetate (DCA) and a cardioprotective or hemodynamic drug, wherein DCA is present in an amount sufficient to ameliorate at least one of the negative side effects of the drug when administered to a subject, wherein the at least one negative side effect is selected from an effect on glucose oxidation, glycolysis, heart rate, peak systolic pressure, cardiac output, oxygen consumption, coronary flow, fatty acid oxidation, cardiac efficiency, aortic outflow, cardiac work, and heart rate×peak systolic pressure (HR×PSP).
Dependencies are inferred from the claim text.