Peptide sequence for modulation of delta protein kinase c
AssigneeNational Institues of Health (Nih), U.S. Dept of Health and Human Service U.S. Government
InventorsDaria D. Mochly-Rosen, Viktoria Kheifets, Deborah Schechtman, Koichi Inagaki, Yasuki Kihara
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Abstract
A peptide identified from the annexin V protein sequence and having the ability to modulate the activity of delta protein kinase C (PKC) is described. The peptide and variants thereof bind to delta PKC and are effective to regulate delta PKC mediated cellular responses. In particular the annexin V peptide is able to inhibit protein-protein interaction with delta PKC, blocking intracellular translocation of delta PKC. Inhibition of delta PKC translocation confers protection to tissue at risk of exposure to ischemia or hypoxia or to reperfusion injury.
Claims17
A purified peptide having at least 50% amino acid identity over the complete sequence of LQANRDPD (SEQ ID NO:1) and which possesses delta-protein kinase C (PKC) binding activity.
A composition comprising a peptide having at least 50% amino acid identity over the complete sequence of LQANRDPD (SEQ ID NO:1) and which possesses delta-PKC binding activity and a pharmaceutically acceptable carrier.
A purified peptide comprising an amino acid sequence of LQANRDPD (SEQ ID NO:1).
A method for regulating a cellular response mediated by delta PKC or for protecting tissue from damage due to ischemia or reperfusion, comprising
- administering a composition comprised of a peptide having at least 50% amino acid identity over the complete sequence of LQANRDPD (SEQ ID NO:1) and which possesses delta-PKC binding activity, and a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.