Novel E. coli O157:H7 Bacteriophage and Uses Thereof
AssigneeIntralytix, Inc.
InventorsGary PASTERNACK, Alexander Sulakvelidze
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Abstract
The present invention is directed to isolated bacteriophage having strong lytic activity against strains of E. coli O157:H7, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of E. coli O157:H7 in various settings.
Claims10
A substantially pure bacteriophage composition comprising the isolated bacteriophages ECML-117 or ECML-134 deposited under ATCC accession Nos. PTA-7950 and PTA-7949 and variants thereof, wherein said variants retain the phenotypic characteristics of said bacteriophage, and wherein said bacteriophage and variants thereof have lytic activity against E. coli O157:H7 strains (the “Targeted Bacteria”).
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A method for the prevention of foodborne illnesses caused by E. coli O157:H7 strains, comprising contacting a food product or products with a microbial growth inhibiting effective amount of a bacteriophage composition comprising the isolated bacteriophages ECML-117 or ECML-134 deposited under ATCC accession Nos. PTA-7950 and PTA-7949, and variants thereof, wherein said variants retain the phenotypic characteristics of said bacteriophage, and wherein said bacteriophage and variants thereof have lytic activity against E. coli O157:H7 strains (the “Targeted Bacteria”).
A method for the reduction of the incidence of foodborne illnesses caused by E. coli O157:H7 strains, comprising contacting a food product or products with a microbial growth inhibiting effective amount of a bacteriophage composition comprising the isolated bacteriophages ECML-117 or ECML-134 deposited under ATCC accession Nos. PTA-7950 and PTA-7949, and variants thereof, wherein said variants retain the phenotypic characteristics of said bacteriophage, and wherein said bacteriophage and variants thereof have lytic activity against E. coli O157:H7 strains (the “Targeted Bacteria”).
Dependencies are inferred from the claim text.