Methods and Compositions for the Treatment of Autoimmune Disorders Using Clofarabine
AssigneeGenzyme Corporation
InventorsChristopher B. Wood, Stuart William Gordon Smith
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Abstract
This invention relates to methods of treating or preventing an autoimmune disorder comprising the administration of clofarabine or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, prodrug or metabolite thereof to a patient in need of such treatment. The invention further relates to methods of treating or preventing an autoimmune disorder comprising the administration of clofarabine or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, prodrug or metabolite thereof and an additional therapeutic agent to a patient in need of such treatment.
Claims37
A method of treating, managing or preventing an autoimmune disorder which comprises administering to a patient in need of such treatment a therapeutically or prophylactively effective amount of clofarabine or a pharmaceutically acceptable salt, stereoisomer, solvate, hydrate, clathrate, prodrug or metabolite thereof.
A dosage form which comprises clofarabine or a pharmaceutically acceptable prodrug, salt, stereoisomer, solvate, hydrate, clathrate, prodrug or metabolite thereof.
A high dose pharmaceutical composition for the treatment of an autoimmune disorder which comprises about 5 to about 1000 mg of clofarabine, or a pharmaceutically acceptable salt, hydrate, clathrate, solvate, prodrug, metabolite or stereoisomer thereof and a pharmaceutically acceptable carrier.
A method of treating multiple sclerosis which comprises administering to a patient in need of such treatment from about 1.25 mg/kg/day to about 80 mg/kg/day of clofarabine or a pharmaceutically acceptable salt, stereoisomer, solvate, hydrate, clathrate, prodrug or metabolite thereof.
Dependencies are inferred from the claim text.