Thrombopoietin mimetics
AssigneesSmithKline Bee cham Corporation, Glaxo Group Limited
InventorsKevin J. Duffy, Connie Erickson-Miller, Daniel F. Eppley, Julian Jenkins, Juan I. Luengo, Nannan Liu, Alan T. Price, Antony N. Shaw, Sophie Visonneau, Kenneth Wiggal
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Abstract
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
Claims15
1-50. (canceled)
A method for enhancing platelet production in a human in need thereof which comprises administering to such human a therapeutically effective amount of a compound having the following formula:
- wherein Q is selected from —COOH and tetrazol-5-yl;
- or a pharmaceutically acceptable salt thereof.
A method for enhancing platelet production obtained from a human donor which comprises administering to such donor a therapeutically effective amount of a compound having the following formula:
- wherein Q is selected from —COOH and tetrazol-5-yl;
- or a pharmaceutically acceptable salt thereof;
- prior to platelet pheresis, blood donation or platelet donation.
Dependencies are inferred from the claim text.