Methods of promoting cartilage healing or cartilage integration
OwnerGregory D. Jayinventor
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Abstract
The present invention provides methods of promoting cartilage healing or integration that include reducing the effective concentration of lubricin found in the extracellular matrix that is in contact with cartilaginous tissue.
Claims45
A method of promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a compound that inhibits the post-translational glycosylation of lubricin in a cell, thereby reducing the effective concentration of lubricin in the extracellular matrix that contacts cartilaginous tissue.
6-26. (canceled)
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising an antisense first nucleic acid sequence of sufficient length to inhibit the synthesis of lubricin in a mammalian cell, wherein said first nucleic acid sequence is complementary to a portion of a second nucleic acid sequence, or one substantially identical to it, that encodes lubricin, thereby reducing the effective concentration of lubricin in extracellular matrix that contacts cartilaginous tissue.
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising double stranded RNA (dsRNA) in an amount sufficient to inhibit the synthesis of lubricin in a mammalian cell, wherein said agent hybridizes to a portion of a second nucleic acid sequence that encodes lubricin, thereby reducing the effective concentration of lubricin in extracellular matrix that contacts cartilaginous tissue.
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising a cytokine capable of reducing the amount of lubricin synthesized by a mammalian cell or increasing the amount of a proteolytic enzyme synthesized by said cell, thereby reducing the effective concentration of lubricin in extracellular matrix that contacts cartilaginous tissue.
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising a surfactant capable of reducing the effective concentration of lubricin in extracellular matrix that contacts said tissue.
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising an antibody that binds to lubricin and is capable of reducing the effective concentration of lubricin in extracellular matrix (ECM) that contacts said tissue.
A method for promoting healing or integration of cartilaginous tissue in a mammal comprising administering to said mammal a composition comprising a proteolytic enzyme capable of reducing the effective concentration of lubricin in extracellular matrix (ECM) that contacts said tissue, wherein said enzyme effects the proteolysis of lubricin.
Dependencies are inferred from the claim text.