Methods and targets for identifying compounds for regulating rhinovirus infection

A method for identifying compounds for regulating rhinovirus infection, comprising:

• a. contacting at least one compound with a rhinovirus infection model system containing a target selected from the group consisting of genes identified in Table I, proteins encoded by genes of Table I, expression regulators of genes of Table I, receptors of proteins encoded by genes of Table I, products of proteins encoded by genes of Table I, receptors of products of proteins of genes of Table I, and combinations thereof;
• b. further determining whether the compound regulates rhinovirus infection in a rhinovirus infection model system;
• and
• c. identifying those compounds that regulate rhinovirus infection in a rhinovirus infection model system as compounds for regulating rhinovirus infection.

A method for identifying compounds for regulating rhinovirus infection, comprising:

• a. contacting at least one compound with a rhinovirus infection model system containing a target selected from the group consisting of genes identified in Table I, proteins encoded by genes of Table I, expression regulators of genes of Table I, receptors of proteins encoded by genes of Table I, products of proteins encoded by genes of Table I, receptors of products of proteins of genes of Table I, and combinations thereof;
• b. further determining whether the compound regulates response to rhinovirus infection in a rhinovirus infection model system;
• and
• c. identifying those compounds that regulate response to rhinovirus infection in a rhinovirus infection model system as compounds for regulating rhinovirus infection.

A method for identifying compounds for regulating rhinovirus infection:

• a. contacting at least one compound with a cell population expressing a protein encoded by the genes of Table I and identified in Table II
• b. determining and comparing the level of activity of the protein in the cell population that is contacted with the compound to the level of activity of the protein in the cell population that is not contacted with the compound;
• and
• c. identifying those compounds that modulate the activity of the protein in the cell population that is contacted with the compound compared to the activity in the cell population that is not contacted with the compound as compounds for regulating rhinovirus infection.

A method for identifying compounds for regulating a rhinovirus infection, comprising:

• a. contacting at least one compound with a cell population expressing a protein encoded by genes of Table I and identified in Table II;
• b. determining and comparing the level of expression of the protein in the cell population that is contacted with the compound to the level of expression of the protein in the cell population that is not contacted with the compound;
• and
• c. identifying those compounds that modulate the expression of the protein in the cell population that is contacted with the compound compared to the expression of the protein in the cell population that is not contacted with the compound as compounds for regulating rhinovirus infection.

A method for identifying compounds for regulating rhinovirus infection, comprising:

• a. contacting at least one compound with a cell population expressing a gene identified in Table I;
• b. determining and comparing the level of expression of the gene in the cell population that is contacted with the compound to the level of expression of the gene in the cell population that is not contacted with the compound;
• and
• c. identifying those compounds that modulate the expression of the gene in the cell population that is contacted with the compound compared to the expression of the gene in the cell population that is not contacted with the compound as compounds for regulating rhinovirus infection.

A method of monitoring progression of rhinovirus infection, comprising:

• a. determining a gene expression profile for one or more gene involved in regulating rhinovirus infection identified in Table I in a biological sample;
• or preparing a protein expression profile, or protein activity profile of one or more proteins involved in regulating rhinovirus infection identified in Table I in a biological sample from a suitable rhinovirus infection model system;
• b. preparing a similar expression or activity profile as in step (a) after a suitable time after the therapeutic regimen;
• c. repeating step (b) during the course of the therapy and evaluating the data to monitor progression of rhinovirus infection.

A method of monitoring the treatment or progression of a disorder in a patient with symptom development in rhinovirus infection, comprising:

• a. determining a gene expression profile for one or more genes involved in regulating rhinovirus infection identified in Table I in a biological sample;
• or preparing a protein expression profile, or protein activity profile of one or more proteins involved in regulating rhinovirus infection identified in Table I in a biological sample from a subject;
• b. administering a therapeutic regimen to the subject;
• c. preparing a similar expression or activity profile as in step (a) from a biological sample from the subject after a suitable time after the therapeutic regimen;
• d. comparing the profiles prior to the therapy with profiles after the therapy;
• and
• e. repeating the steps (b), (c) and (d) during the course of the treatment or disorder and evaluating the data to monitor efficacy of the treatment or progression of the disorder.