Antibodies to MAGMAS and uses thereof
OwnerMary K. Short, Paul T. Jubinskyinventors
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Abstract
The present invention relates to isolated and purified Magmas protein, isolated and purified nucleic acids encoding Magmas protein, and antibodies to Magmas protein, which interacts with granulocyte macrophage colony stimulating factor (GM-CSF). More specifically, the invention relates to uses of such anti-Magmas antibodies. The invention further relates to a method for diagnosis, prognosis and treatment of diseases, particularly, cancer, Alzheimer's disease and mitochondrial diseases using Magmas sequences and antibodies directed against the Magmas protein or fragments thereof.
Claims11
1-10. (canceled)
A method of detecting cancer comprising the steps of:
- a) providing a biological sample from an individual suspected of having cancer;
- b) analyzing the Magmas protein expression in the sample;
- and c) comparing the expression of Magmas protein in the sample against a normal control, wherein increased expression of the Magmas protein in the sample indicates that the individual is at increased risk for cancer.
A method of treating an individual affected with cancer comprising the steps of administering a therapeutic Magmas blocking amount of a compound that interacts with Magmas such as a Magmas antibody in a pharmaceutically acceptable carrier to an individual having cancer.
A Diagnostic kit for Western blotting or immunohistochemistry to detect the presence of cells expressing Magmas and to quantity the level of expression, containing immunoglobulin specific for human MAGMAS.
Dependencies are inferred from the claim text.