Pre-filled crystallization plates and methods for making and using same
AssigneeQiagen Canada Inc.
InventorsJean-Pascal VIOLA, Christian Houde, Marie-Claude Marchand, David Bouchard
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Abstract
The present invention generally relates to encapsulation of crystallization solutions in pierceable reservoirs in order to prevent evaporation of the crystallization solutions, thereby allowing safe transport/shipping, from a workstation to another workstation, and safe storage of pre-filled microplates used to carry large number of vapor-diffusion crystallization experiments.
Claims8
A hanging-drop crystallization support adapted to be inverted over a well containing a crystallization solution, the hanging drop crystallization support comprising an undersurface defining at least one cavity for confining a droplet of solution containing a precipitating solution and a macromolecule to be crystallized, the cavity having a bottom surface and being sized to receive a predetermined volume of macromolecule solution so that when vapor equilibrium is reached between the crystallization solution and the droplet of solution, the bottom surface of the cavity is still completely covered by the solution.
Dependencies are inferred from the claim text.