Multi-Layered Devices for Analyte Detection
AssigneeKimberly-Clark Worldwide, Inc.
InventorXuedong Song
Life of this patent
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Abstract
A multi-layered device for detecting the presence or absence of an analyte within a test sample is described. The device includes a sensing layer and a control layer. The sensing layer is configured to support a reaction so as to exhibit a signal indicative of the presence or absence of the analyte in the test sample. The control layer is in fluid communication with and vertically adjacent to the sensing layer and includes a reagent capable of inhibiting the reaction and/or other unwanted side reactions at the sensing layer after a certain period of time by diffusive movement of the reagent from the control layer to the sensing layer.
Claims25
A multi-layered device for detecting the presence or absence of an analyte within a test sample, the device comprising:
- a sensing layer, the sensing layer configured to support a reaction so as to exhibit a signal indicative of the presence or absence of the analyte in the test sample;
- and
- a control layer, the control layer being in fluid communication with and vertically adjacent to the sensing layer, the control layer including a reagent capable of inhibiting the reaction at the sensing layer by diffusive movement of the reagent from the control layer to the sensing layer.
A multi-layered device for detecting the presence or absence of an enzyme within a test sample, the device comprising:
- a sensing layer, the sensing layer comprising a substrate capable of being modified in the presence of the enzyme to release a product utilized to indicate the presence or absence of the enzyme in the test sample;
- and
- a control layer, the control layer being in fluid communication with and vertically adjacent to the sensing layer, the control layer including a control reagent capable of inhibiting the reaction at the sensing layer by diffusive movement of the control reagent from the control layer to the sensing layer.
A multi-layered device for detecting the presence or absence of a nitrite within a test sample, the device comprising:
- a sensing layer, the sensing layer comprising an aromatic primary amine and a detection reagent, the aromatic primary amine capable of reacting with a nitrite to form a diazonium ion, the detection reagent capable of reacting with the diazonium ion to form an indicator, the indicator exhibiting a color indicative of the presence or absence of the nitrite in the test sample;
- and
- a control layer, the control layer being in fluid communication with and vertically adjacent to the sensing layer, the control layer including a control reagent capable of inhibiting the reaction at the sensing layer by diffusive movement of the control reagent from the control layer to the sensing layer.
An absorbent article for receiving a bodily fluid suspected of containing an analyte, comprising:
- a substantially liquid impermeable layer;
- a liquid permeable layer;
- an absorbent core positioned between the substantially liquid impermeable layer and the liquid permeable layer;
- and
- a multi-layered device integrated into the article and positioned such that the device is in fluid communication with the bodily fluid when provided by a wearer of the article, the device comprising a sensing layer and a control layer, the sensing layer configured to support a reaction so as to exhibit a signal indicative of the presence or absence of the analyte in the bodily fluid, the control layer being in fluid communication with and vertically adjacent to the sensing layer, the control layer including a reagent capable of inhibiting the reaction at the sensing layer by diffusive movement of the reagent from the control layer to the sensing layer.
Dependencies are inferred from the claim text.