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US 2009/0153153 A1Published application
Multiaperture sample positioning and analysis system
OwnerHorst Vogel, Christian Schmidtinventors
Life of this patent
Estimating the term…
Abstract
Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels.
Claims7
A system for analyzing membranous samples, comprising:
- a carrier with a shelf structure, the shelf structure having an aperture;
- first and second fluid compartments, separated by the carrier, and fluidically connected to one another, in the absence of a membranous sample, via the aperture;
- a membranous sample, selected from the group consisting of cells, organelles, and vesicles, sealed across the aperture, wherein the seal has an electrical resistance of greater than about 1 GΩ;
- and
- first and second electrodes, in electrical contact with the first and second fluid compartments, respectively, wherein the first and second electrodes are adapted to apply and/or measure at least one of an electrical potential and a current from at least a portion of the membranous sample sealed across the aperture.
2 more elements
2-27. (canceled)
A system for analyzing membranous samples, comprising:
- a carrier having an opening, the interior of the opening including a shelf structure;
- first and second fluid compartments, separated by the carrier, and fluidically connected to one another, in the absence of a membrane sample, via the opening;
- first and second electrodes, in electrical contact with the first and second fluid compartments, respectively, wherein the first and second electrodes being adapted to apply and/or measure at least one of an electrical potential and a current from at least a portion of a membranous sample sealed within the opening;
- and
- a membranous sample, selected from the group consisting of cells, organelles, and vesicles, sealing the opening.
2 more elements
29-32. (canceled)
A system for analyzing membranous samples, comprising:
- a carrier having a planar surface and an aperture terminating at the planar surface;
- first and second fluid compartments, separated by the carrier, and fluidically connected, in the absence of a sample, via the aperture;
- a membranous sample, selected from the group consisting of cells, organelles, and vesicles, sealed across the aperture, wherein the seal has an electrical resistance of greater than about 1 gigaohm;
- and
- first and second electrodes, in electrical contact with the first and second fluid compartments, respectively, wherein the first and second electrodes are adapted to apply and/or measure at least one of an electrical potential and a current from at least a portion of the membranous sample sealed across the aperture.
2 more elements
34-75. (canceled)
Dependencies are inferred from the claim text.