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AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMichael Roof, Eric Vaughn, Wesley Johnson
Estimating the term…
A method of predicting the virulence of a new or uncharacterized PRRS virus isolate is provided wherein the isolate is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus isolate of known virulence, as a measure of the virulence of the new or uncharacterized isolate. Additionally, a method of selecting an isolate for inclusion in an immunogenic composition based on the predicted virulence is also provided, together with compositions incorporating attenuated forms of viruses predicted to be virulent.
A method of predicting the virulence of a PRRS virus isolate of unknown virulence, comprising the steps of administering a quantity of said PRRS virus isolate into PRRS-free swine, allowing the virus to replicate in said swine for a period of from about 3-15 days, measuring the rate of virus growth and/or the magnitude of viremia during said period, and comparing said rate of growth or viremia magnitude with the rate of growth and/or viremia magnitude of a PRRS virus isolate of known virulence as a predictor of virulence of the PRRS isolate of unknown virulence.
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