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US 2009/0143286 A1Published application
Methods and Compositions for Regenerating Articular Cartilage
AssigneeGenera Doo
InventorsSlobodan Vukicevic, Mislav Jelic
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Abstract
Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.
Claims27
A method of treating a partial thickness defect or area of reduced volume of articular cartilage in the joint of an individual comprising:
- administering to the partial thickness defect or area of reduced volume of articular cartilage an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into the defect or area, and
- administering to the partial thickness defect or area of reduced volume of articular cartilage a columnar growth promoting agent that promotes columnar growth of chondrocytes in the defect or area.
A composition for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising:
- an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, and
- a columnar growth promoting agent that promotes columnar growth of chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage.
27-39. (canceled)
Dependencies are inferred from the claim text.