Chlamydia polypeptides and corresponding dna fragments and uses thereof
AssigneeAventis Pasteur Limited
InventorsAndrew D. Murdin, Raymond P. Oomen, Joe Wang, Pamela Dunn
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Abstract
The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.
Claims36
A vaccine vector comprising an isolated nucleic acid molecule operably linked to a promoter functional in a mammalian cell, wherein the nucleic acid molecule encodes a polypeptide selected from any of:
- (a) SEQ ID No:3 or 4;
- (b) an immunogenic fragment consisting of at least 50 consecutive amino acids from SEQ ID No:3;
- and
- (c) a polypeptide which has been modified without loss of immunogenicity, wherein said modified polypeptide is at least 95% identical in amino acid sequence to SEQ ID NO:3 or 4;
- wherein the polypeptide, when used to immunize an animal, confers immunoprotection to the animal against Chlamydia.
Dependencies are inferred from the claim text.