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US 2009/0136451 A1Published application
Humanised Baculovirus
OwnerNorman Maitland, Lindsay Stanbridgeinventors
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Abstract
We describe a modified baculovirus that has increased specific cell targeting and decreased non-specific targeting by mutation of a heparin sulphate binding motif.
Claims45
A baculovirus wherein the genome of the virus has been modified to include
- i) a nucleic acid molecule that encodes a therapeutic agent;
- ii) a nucleic acid molecule that encodes a polypeptide that functions to specifically target the baculovirus to at least one cell type;
- wherein the baculovirus genome is further modified by addition, deletion or substitution of at least one nucleotide base in a part of a baculovirus gene that encodes an amino acid motif that binds heparin sulphate expressed by a cell.
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Dependencies are inferred from the claim text.