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US 2009/0099266 A1Published application
Antifungal nail coat and method of use
AssigneeNexmed Holdings, Inc.
InventorsStanley W. Kepka, Y. Joseph Mo, Hang-Yong Wang, Mingqi Lu, William R. Pfister
Life of this patent
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Abstract
Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
Claims22
An antifungal nail coat composition comprising:
- a fungicidal amount of an allylamine;
- an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or pharmaceutically acceptable acid addition salt thereof;
- a film-forming amount of a hydrophilic polymer;
- and
- a pharmaceutically acceptable, volatile organic carrier,
- the composition providing a substantially water-soluble, fungicidal coating on contacting a fungally susceptible or infected nail.
3 more elements
An antifungal nail coat composition comprising, on a total composition weight basis:
- about 0.5 to about 10 weight percent terbinafine hydrochloride;
- about 0.1 to about 25 weight percent dodecyl-2-(N,N-dimethylamino) isopropionate hydrochloride;
- about 0.1 to about 10 weight percent benzyl alcohol;
- about 0.1 to about 5 percent polyvinylpyrrolidone;
- and
- ethanol comprising the remainder.
3 more elements
Dependencies are inferred from the claim text.