Method of treating pulmonary edema or pulmonary inflammation
OwnerTomas Navratil, Kurt E. Brubaker +3inventors
InventorsTomas Navratil, Kurt E. Brubaker, Jose L. Boyer, Ward M. Peterson, Ramesh Krishnamoorthy
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OwnerTomas Navratil, Kurt E. Brubaker +3inventors
InventorsTomas Navratil, Kurt E. Brubaker, Jose L. Boyer, Ward M. Peterson, Ramesh Krishnamoorthy
Estimating the term…
The invention provides a method for preventing or treating pulmonary edema and/or pulmonary inflammation in a subject by the administration of at least one nucleotidase. The subject is preferably a human subject. The nucleotidase is preferably of a mammalian origin, such as a human origin. The NTPDase and NPP families of nucleotidases are particularly useful for the present invention. The method reduces the bioavailability of in situ signaling extracellular nucleotides, thereby disturbing the pathological pathways in ventilator-induced lung injury (VILI) and respiratory syncytial virus infection (RSV) and other disorders such as chronic obstructive pulmonary disorder. Local administration such as inhalation is a preferred route of administration.
A method for preventing or treating pulmonary edema and/or pulmonary inflammation in a human subject, comprising:
A method for treating pulmonary edema and/or pulmonary inflammation in a subject, comprising:
A method of preventing or treating pulmonary edema and/or pulmonary inflammation comprising administering to a subject an effective amount of a nucleotidase selected from the group consisting of:
Dependencies are inferred from the claim text.