Assays
AssigneeInverness Medical Switzerland GmbH
InventorsLeong Ng, Sarah Johnson, Steve Eida, Paul Sheard
Life of this patent
Estimating the term…
Abstract
Methods and assays for monitoring the cardiac health of a subject are provided. The method involves the detection of a urotensin surrogate in a sample leading to a more accurate and reliable diagnosis of early or late stages of decompensated heart failure, heart failure, risk of a heart failur in a subject than the measurement of the cyclic peptide of urotensin alone.
Claims47
A method for monitoring the cardiac health of a subject comprising detecting a level of a urotensin surrogate in a sample from a subject.
A method of assaying a sample for urotensin comprising detecting a level of a urotensin surrogate in a sample from a subject.
A polypeptide comprising the sequence:
- -EDARCTPEEL-.
37-38. (canceled)
An antibody derived from a mammal immunized with a synthetic polypeptide, the polypeptide comprising the sequence:
- -EDARCTPEELC-.
40-45. (canceled)
A method of detecting a urotensin surrogate in a sample comprising contacting the sample with an antibody having affinity for at least a portion of amino acids 1-113 of SEQ ID NO:
- 1.
47-52. (canceled)
A kit for monitoring the cardiac health of a subject comprising:
- instructions for taking a sample from the subject;
- one or more reagents for measuring the level of a urotensin surrogate in the sample.
54-70. (canceled)
A method of detecting a urotensin surrogate in a sample comprising contacting the sample with an antibody having affinity for at least a portion of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5.
72-74. (canceled)
A method of detecting a urotensin surrogate in a sample comprising contacting the sample with an antibody having affinity for at least a portion of a linear peptide having the sequence of SEQ ID NO:
- 6.
76-79. (canceled)
Dependencies are inferred from the claim text.