Hydrogenase deficient bacterial strains
AssigneeUniv. of Georgia Research Foundation, Inc.
InventorsRobert J. Maier, John S. Gunn
Life of this patent
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Abstract
The present disclosure describes pathogenic bacteria that have been modified to be deficient in NiFe hydrogenase activity; compositions comprising such modified bacteria, and the use of such bacteria to protect animals from pathogenic enteric bacterial infections.
Claims17
An isolated bacterium that has a greater than 75% reduction in hydrogenase activity relative to a wild type strain.
A method of inducing an immune response in a mammal against a pathogenic bacterium said method comprising the step of administering to said mammal a composition comprising live bacterium, wherein the bacterium has been modified to prevent the expression of a functional NiFe hydrogenase protein.
A method of protecting a mammalian species against an infection with pathogenic Salmonella, E. coli, Shigella, or Campylobacter, said method comprising the step of administering to the subject a live bacterium, selected from the group consisting of Salmonella, E. coli, Shigella, and Campylobacter, wherein the bacterium has been modified to prevent expression of a functional NiFe hydrogenase protein.
Dependencies are inferred from the claim text.