Product
AssigneeAffitech AS
InventorMarike Stassar
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Abstract
The invention relates to tumor-specific binding proteins and all uses thereof. In particular, the invention relates to antibodies or antibody fragments specific for antigens or molecules on cancer cells (CD166) and to methods of use thereof. Binding proteins comprising specific heavy and light chain CDRs are disclosed wherein the binding protein shows a measurable or significant binding to breast cancer cell line MDA-MB 231 but shows insignificant or unmeasurable binding to granulocytes or peripheral blood lymphocytes (PBLs).
Claims74
A binding protein which comprises at least one light chain variable (VL) region that comprises three CDRs, wherein said light chain variable region comprises:
- (i) a VL CDR1 that comprises the amino acid sequence of SEQ ID NO:
- 6,
- (ii) a VL CDR2 that comprises the amino acid sequence of SEQ ID NO:
- 7, and
- (iii) a VL CDR3 that comprises the amino acid sequence of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.