Human salivary gland-origin stem cell
AssigneeBios Research Institute Inc.
InventorsFumio Endo, Kenji Okumura, Kimitoshi Nakamura
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Abstract
A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.
Claims3
A method for obtaining insulin-positive cells, comprising culturing in vitro human stem cells which are nestin-positive and albumin-positive, which are induced by culturing human salivary gland cells in vitro, and which can be differentiated to insulin-positive cells and glucagon-positive cells by culture in vitro to induce insulin-positive cells, and collecting the induced insulin-positive cells.
A method for obtaining glucagon-positive cells, comprising culturing in vitro human stem cells which are nestin-positive and albumin-positive, which are induced by culturing human salivary gland cells in vitro, and which can be differentiated to insulin-positive cells and glucagon-positive cells by culture in vitro to induce glucagon-positive cells, and collecting the induced glucagon-positive cells.
Dependencies are inferred from the claim text.