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AssigneeBioavailability, Inc.
InventorsSteven B. Harris, Nick J. Huang
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A method and composition are presented for enhancing the dissolution and bioavailable properties of CoQ10 nutritional supplements and/or therapeutic agents for a human being and other mammals. The method includes preparing an anhydrous self-microemulsifying base composition by combining: CoQ10, a water-immiscible, and a non-ionic surfactant, containing polyethylene glycol. For an orally administered CoQ10 nutritional supplement in a capsule formulation, a unit dosage from the composition is added to a dissolvable capsule, preferably a soft gelatin capsule, in order to form the nutritional supplement. When a capsule containing the self-microemulsifying composition enters the digestive tract, the temperature of the body's digestive juices warms the composition, causing any of the CoQ10 that may have re-crystallized out of the composition to become re-dissolved into the composition before the capsule dissolves. The re-dissolution of CoQ10 is bioavailable when the capsule dissolves. Upon dissolution of the capsule, the self-microemulsifying composition comes into contact with the digestive juices and naturally forms micellar-type bioavaible microemulsions, consisting of micelles containing CoQ10. In addition to the capsule formulation, the invention includes parenteral, liquid, topical and ophthalmic formulations.
A method of preparing an orally administrable CoQ10 nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ nutritional supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally or ophthalmically administrable CoQ10 therapeutic agent for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally or ophthalmically administrable CoQ10 therapeutic agent for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally or ophthalmically administrable CoQ10 therapeutic agent for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally administrable CoQ10 therapeutic agent in intramuscular form for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally administrable CoQ10 therapeutic agent in intramuscular form for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally administrable CoQ10 therapeutic agent in intramuscular form for a human being and other mammals, comprising the following steps:
A method of preparing a CoQ10 supplement in topical form for a human being and other mammals, comprising the following steps:
A method of preparing a CoQ10 supplement in topical form for a human being and other mammals, comprising the following steps:
A method of preparing a CoQ10 supplement in topical form for a human being and other mammals, comprising the following steps combining a water-immiscible solvent, a molten or liquid non-ionic surfactant and CoQ10, while maintaining the preparation temperature of the composition at about 27° C. to about 40° C., the solvent included in the composition in an amount of up to about 30% by weight of the composition, the surfactant included in the composition in an amount of about 60% to about 82% by weight of the composition, and the CoQ10 included in the composition in an amount of about 2% to about 20% by weight of the composition, whereby the base composition can be used directly as a topical lotion, salve or cream.
A method of preparing a CoQ10 supplement in capsule form for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally or ophthalmically administrable CoQ10 therapeutic agent for a human being and other mammals, comprising the following steps:
A method of preparing a parenterally administrable CoQ10 therapeutic agent for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human being and other mammals, comprising the following steps:
A method of preparing an orally administrable CoQ10 nutritional supplement in liquid form for a human being and other mammals, comprising the following steps:
A method of preparing a CoQ10 supplement in topical form for a human being and other mammals, comprising the following steps:
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
An orally administrable CoQ nutritional supplement for a human being and other mammals, comprising:
A base composition comprising a non-ionic surfactant, included in said composition in an amount of about 60% to about 82% by weight of the composition;
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
A parenterally or ophthalmically administrable CoQ 0 therapeutic agent for a human being and other mammals, comprising:
A parenterally administrable CoQ10 therapeutic agent for a human being and other mammals, comprising:
A CoQ 0 supplement in topical from for a human being and other mammals comprising:
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
A parenterally or ophthalmically administrable CoQ10 therapeutic agent for a human being and other mammals, comprising:
A parenterally administrable CoQ10 therapeutic agent for a human being and other mammals, comprising:
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
An orally administrable CoQ10 nutritional supplement for a human being and other mammals, comprising:
A CoQ10 supplement in topical form a human being and other mammals comprising:
A base composition comprising a non-ionic surfactant, included in said composition in an amount of about 97% to about 98% by weight of the composition;
Dependencies are inferred from the claim text.