Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs

A compound selected from:

• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(5-(2-chloropyridylmethyl))aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(3-(2-chloropyridylmethyl))aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(4-(3,5-dimethylisoxazolylmethyl))-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-aminocarbonylphenyl)-N-(3-pyridylmethyl)aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(5-(4-chloropyridylmethyl))aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxy-4-chlorophenyl)-N-(3-pyridylmethyl)aniline,
• 3,4-Bisdifluoromethoxy-N-(4-(1-pyrrol-1-yl)phenyl)-N-(3-pyridylmethyl)aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(5-(4-methoxypyridylmethyl))aniline,
• 3-Cyclopentyloxy-4-methoxy-N-phenyl-N-(3-(2-ethoxypyridylmethyl))aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-methylaminocarbonylphenyl)-N-(3-pyridylmethyl)-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-(2-hydroxyethyl)aminocarbonylphenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxyphenyl)-N-(5-(4-chloropyridylmethyl))-aniline,
• 3,4-Bisdifluoromethoxy-N-(3-carboxyphenyl)-N-(4-(3,5-dichloropyridylmethyl))aniline,
• 3-Cyclopentyloxy-4-methoxy-N-cyclohexylaniline,
• 3-Cyclopentyloxy-4-hydroxy-N-(3-tert-butyloxycarbonylphenyl)-N-(3-pyridylmethyl))-aniline,
• 3-Cyclopentyloxy-4-hydroxy-N-(3-carboxyphenyl)-N-(3-pyridylmethyl))aniline,
• 4-Methoxy-3-(R)-tetrahydrofuryloxy-N-(3-carboxy-4-chlorophenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxyphenyl)-N-(4-(3-chloropyridylmethyl))-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-phenyl-N-(4-(3-chloropyridylmethyl)aniline,
• 4-Methoxy-3-(R)-tetrahydrofuryloxy-N-(3-carboxyphenyl)-N-(4-pyridylmethyl)aniline,
• 4-Methoxy-3-(R)-tetrahydrofuryloxy-N-(3-pyridyl)-N-(4-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxyphenyl)-N-(4-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxy-3-chlorophenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxy-3-methylphenyl)-N-(3-pyridylmethyl)-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxy-3-fluorophenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxy-4-chlorophenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxy-4-fluorophenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxyphenyl)-N-(4-(3,5-dichloropyridylmethyl))-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxyphenyl)-N-(4-(3,5-dichloropyridylmethyl))-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-carboxyphenyl)-N-(4-(3-chloropyridylmethyl))-aniline,
• 4-Methoxy-3-(R)-tetrahydrofuryloxy-N-(4-carboxyphenyl)-N-(4-(3,5-dichloropyridylmethyl))aniline,
• 4-Methoxy-3-(R)-tetrahydrofuryloxy-N-(3-carboxyphenyl)-N-(4-(3,5-dichloropyridylmethyl))aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxy-4-methylphenyl)-N-(3-pyridylmethyl)-aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-amino-3-carboxyphenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(3-carboxy-4-trifluoromethylphenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-acetamido-3-carboxyphenyl)-N-(3-pyridylmethyl)aniline,
• 3-Cyclopentyloxy-4-methoxy-N-(4-(N,N-bis(2,4-dimethoxy)benzyl)-aminosulfonylphenyl)-N-(3-pyridylmethyl)aniline,
• Methyl N-(3-cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoate,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-bromoaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(N-piperidinylmethyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(N-morpholinomethyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(N,N-diethylamino)methyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-methylthioaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-methylthioaniline,
• N-(3-(2-Hydroxy)cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-2-aminoisonicotinic acid,
• N-(3-Hydroxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-[3-(3-Hydroxy)cyclopentyloxy-4-methoxyphenyl]-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-amino-2-chlorobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-amino-6-methylbenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(5-fluoro-3-pyridylmethyl)-4-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(5-(1,3-dimethylpyrazolylmethyl)-3-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-5-trifluoromethyl-3-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-6-trifluoromethyl-3-aminobenzoic acid,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclopentoxy-4-methoxyphenyl)-N-(5-fluoro-3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclopentoxy-4-methoxyphenyl)-N-(5-fluoro-3-pyridylmethyl)-4-aminobenzoic acid,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclobutyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclohexyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cycloheptyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(4-Methoxy-3-(4-pyranyloxy)phenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-[2.2.2-Bicyclooctanyl]oxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclopentoxy-4-methoxyphenyl)-N-(2,6-difluorobenzyl)-3-aminobenzoic acid,
• N-(3-Cyclopentoxy-4-methoxyphenyl)-N-(4-(3,5-dimethylisoxazolyl))-3-aminobenzoic acid,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-amino-5-fluorobenzoic acid,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-3-amino-5-fluorobenzoic acid,
• N-(3,4-Bis-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-3-amino-5-fluorobenzoic acid,
• N-(3-Cyclohexyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(4-Methoxy-3-(2-(2-Pyridylethoxy))phenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(2-(3-pyridylethyl))-3-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-chloro-4-(5-(2H)-tetrazolyl)aniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-chloro-4-(5-(2H)-tetrazolyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(4-(3,5-dichloropyridyl)methyl)-4-(5-(2H)-tetrazolyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-morpholinyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-N-methyl-1-piperazinyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(1-piperazinyl)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(N,N-diethylamino)aniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-methanesulfonylaniline,
• N-(4-methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-methylsulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(5-chloro-3-pyridylmethyl)-3-aminobenzoic acid,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-fluorobenzyl)-4-aminobenzoic acid,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-[4-Methoxy-3-(1-propyl)oxyphenyl]-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-[4-Methoxy-3-(2-propyl)oxyphenyl]-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclopropylethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(3-Cyclobutylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-hydroxymethylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-hydroxymethylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-piperidinyl)sulfonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-methylsulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-(2-methylphenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-phenylsulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-phenylsulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-methylsulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(4-(3,5-dichloropyridylmethyl)-4-phenylsulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(4-(3,5-dichloropyridylmethyl)-4-methylsulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-ethylsulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-methoxyphenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-methylsulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-phenylsulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-phenylsulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(5-fluoro-3-pyridylmethyl)-3-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-methylsulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-phenylsulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(1,1-dimethylethyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(5-chloro-2-thienyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-thienyl)sulfonylaminocarbonylaniline,
• N-(3,4-Bisdifluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3,4-Bisdifluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3,4-Bisdifluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-cyanophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2-thienyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-cyanophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(2,6-difluorobenzyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-fluorobenzyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(3-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(4-Difluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-ethylsulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-(3-cyanophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-(3-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Cyclopentyloxy-4-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(2,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(3,4-Bisdifluoromethoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-methylsulfonylaminocarbonylaniline,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-ethylsulfonylaminocarbonylaniline,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(3-chlorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(3,4-difluorophenyl)sulfonylaminocarbonylaniline,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(2-thienyl)sulfonylaminocarbonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-cyclopentylmethylcarbonylaminosulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-fluorophenyl)carbonylaminosulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(1-ethyl-5-methylpyrazol-4-yl)carbonylaminosulfonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-(4-methylpiperazin-1-yl)sulfonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-(4-morpholinyl)sulfonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(4-methylpiperazin-1-yl)sulfonylaniline,
• N-(3-Cyclopentyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-(4-morpholinyl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-(4-methylpiperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-methylpiperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-morpholinyl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-3-(4-morpholinyl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-ethylpiperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-cyclohexylpiperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(3,5-dimethylpiperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-(2-pyridyl)piperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(4-(4-fluorophenyl)piperazin-1-yl)sulfonylaniline,
• N-(4-Methoxy-3-(3R)-tetrahydrofuranyloxyphenyl)-N-(3-pyridylmethyl)-4-(2,5-dimethylpyrrol-1-yl)sulfonylaniline,
• and pharmaceutically acceptable salts thereof,
• wherein compounds that are optically active can be in the form of their separate enantiomers or mixtures thereof, including racemic mixtures.

A method for enhancing cognition in a patient in whom such enhancement is desired comprising administering to said patient an effective amount of a compound according to Formula I:

• wherein
• R1 is H or alkyl having 1 to 4 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times by halogen;
• R2 is alkyl having 1 to 12 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times by halogen, hydroxy, cyano, C1-4-alkoxy, oxo or combinations thereof, and wherein optionally one or more —CH2CH2— groups is replaced in each case by —CH═CH— or —C≡C—,
• cycloalkyl having 3 to 10 carbon atoms, which is unsubstituted or substituted one or more times by halogen, hydroxy, oxo, cyano, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted in the cycloalkyl portion and/or the alkyl portion one or more times by halogen, oxo, cyano, hydroxy, C1-4-alkyl, C1-4-alkoxy or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, cyano, or combinations thereof,
• arylalkyl in which the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, which the arylalkyl radical is unsubstituted or is substituted in the aryl portion one or more times by halogen, CF3, OCF3, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, nitro, cyano, methylenedioxy, ethylenedioxy, or combinations thereof, and wherein in the alkyl portion one or more —CH2CH2— groups are each optionally replaced by —CH═CH— or —C≡C—, and one or more —CH2— groups are each optionally replaced by —O— or —NH— and/or the alkyl portion is optionally substituted by halogen, oxo, hydroxy, cyano, or combinations thereof, or
• a partially unsaturated carbocyclic group having 5 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, hydroxy, nitro, cyano, oxo, or combinations thereof;
• R3 is heteroarylalkyl group, wherein the heteroaryl portion may be partially or fully saturated and has 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, the heteroarylalkyl group is unsubstituted or substituted one or more times in the heteroaryl portion by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, cyano, trifluoromethyl, CF3O, nitro, oxo, amino, alkylamino wherein the alkyl group has 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, or combinations thereof and/or substituted in the alkyl portion by halogen, cyano, or methyl or combinations thereof;
• R4 is aryl having 6 to 14 carbon atoms and which is substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkenyl having 2 to 12 carbon atoms, alkynyl having 2 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, OCF3, amino, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, pyrrolyl, tetrazole-5-yl, 2(-heterocycle)tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, alkylsulfonyl having 1 to 12 carbon atoms, phenoxy, trialkylsilyloxy wherein each alkyl group has 1 to 12 carbon atoms, R5-L-, or combinations thereof;
• R5 is H,
• alkyl having 1 to 8 carbon atoms, which is unsubstituted or substituted one or more times with halogen, C1-4-alkyl, C1-4-alkoxy, oxo, or combinations thereof,
• alkylamino or dialkylamino wherein each alkyl portion has independently 1 to 8 carbon atoms,
• a partially unsaturated carbocycle-alkyl group wherein the carbocyclic portion has 5 to 14 carbon atoms and the alkyl portion has 1 to 5 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, nitro, cyano, oxo, or combinations thereof,
• cycloalkyl having 3 to 10 carbon atoms, which is unsubstituted or substituted one or more times by halogen, hydroxy, oxo, cyano, alkoxy having 1 to 12 carbon atoms, alkyl having 1 to 4 carbon atoms, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted in the cycloalkyl portion and/or the alkyl portion one or more times by halogen, oxo, cyano, hydroxy, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms or combinations thereof,
• aryl having 6 to 14 carbon atoms and which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, amino, aminomethyl, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, alkylsulfonyl having 1 to 12 carbon atoms, phenoxy, cycloalkyl having 3 to 10 carbon atoms, aryl having 6 to 14 carbon atoms which is substituted unsubstituted, heteroaryl having one or two rings and a total number of 5 to 10 ring atoms wherein at least one of the ring atoms is a heteroatom and which is substituted unsubstituted, or combinations thereof, or
• arylalkyl having 7 to 19 carbon atoms, wherein the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, arylalkyl radical is unsubstituted or substituted, in the aryl portion, one or more times by halogen, trifluoromethyl, CF3O, nitro, amino, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, amino, alkylamino having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms and/or substituted in the alkyl portion by halogen, cyano, or methyl,
• L is a single bond or a divalent aliphatic radical having 1 to 8 carbon atoms wherein one or more —CH2— groups are each optionally replaced by —O—, —S—, —NR6—, —SO2NH—, —NHSO2—, —SO2NR6—, —NR6SO2—, —CO—, —NR6CO—, —CONR6—, —NHCONH—, —OCONH, —NHCOO—, —SCONH—, —SCSNH—, or —NHCSNH—;
• and
• R6 is H,
• alkyl having 1 to 8 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times with halogen, C1-4-alkyl, C1-4-alkoxy, oxo, or combinations thereof;
• arylalkyl having 7 to 19 carbon atoms, wherein the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, arylalkyl radical is unsubstituted or substituted, in the aryl portion, one or more times by halogen, trifluoromethyl, CF3O, nitro, amino, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, alkylamino having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, and/or substituted in the alkyl portion by halogen, cyano, or methyl;
• aryl having 6 to 14 carbon atoms and which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, amino, aminomethyl, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, or alkylsulfonyl having 1 to 12 carbon atoms;
• or a pharmaceutically acceptable salt thereof;
• with the provisos that:
• (a) R4 is at least monosubstituted by R5-L in which L is a divalent aliphatic radical having 1 to 8 carbon atoms wherein at least one —CH2— group is replaced by —SO2NR6— or —NR6SO2— in which R6 is aryl or arylalkyl which in each case is substituted or unsubstituted;
• (b) R4 is at least monosubstituted by R5-L in which L is a divalent aliphatic radical having 1 to 8 carbon atoms wherein at least one —CH2— group is replaced by —NR6—, —SO2NR6—, —NR6SO2—, —NR6CO—, or —CONR6— and R5 is aryl or arylalkyl which in each case is substituted or unsubstituted;
• (c) R4 is at least monosubstituted by R5-L in which R5 is aryl or a heterocyclic group each being substituted by cycloalkyl, aryl or heteroaryl;
• (d) R4 is at least monosubstituted by R5-L in which L is —SO—, —SO2—, —CONR6SO2—, —SO2NR6CO—, or —SO2NR6—, with the further proviso that when R4 is at least monosubstituted by R5-L in which L is —SO2NR6—, then R6 is other than H;
• or
• (e) said compound is selected from
• 3-Cyclopentyloxy-4-methoxy-N-(3-tert-butyloxycarbonylphenyl)-N-(3-pyridylmethyl))-aniline,
• N-(3,4-Bis-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclobutyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3,4-Dimethoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Isopropoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3,4-Dimethoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• and pharmaceutically acceptable salts thereof.

A method of treating a patient suffering from an allergic or inflammatory disease comprising administering to said patient an effective amount of a compound according to Formula I:

• wherein
• R1 is H or alkyl having 1 to 4 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times by halogen;
• R2 is alkyl having 1 to 12 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times by halogen, hydroxy, cyano, C1-4-alkoxy, oxo or combinations thereof, and wherein optionally one or more —CH2CH2— groups is replaced in each case by —CH═CH— or —C≡C—,
• cycloalkyl having 3 to 10 carbon atoms, which is unsubstituted or substituted one or more times by halogen, hydroxy, oxo, cyano, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted in the cycloalkyl portion and/or the alkyl portion one or more times by halogen, oxo, cyano, hydroxy, C1-4-alkyl, C1-4-alkoxy or combinations thereof,
• aryl having 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, cyano, or combinations thereof,
• arylalkyl in which the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, which the arylalkyl radical is unsubstituted or is substituted in the aryl portion one or more times by halogen, CF3, OCF3, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, nitro, cyano, methylenedioxy, ethylenedioxy, or combinations thereof, and wherein in the alkyl portion one or more —CH2CH2— groups are each optionally replaced by —CH═CH— or —C≡C—, and one or more —CH2— groups are each optionally replaced by —O— or —NH— and/or the alkyl portion is optionally substituted by halogen, oxo, hydroxy, cyano, or combinations thereof, or
• a partially unsaturated carbocyclic group having 5 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, hydroxy, nitro, cyano, oxo, or combinations thereof;
• R3 is heteroarylalkyl group, wherein the heteroaryl portion may be partially or fully saturated and has 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, the heteroarylalkyl group is unsubstituted or substituted one or more times in the heteroaryl portion by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, cyano, trifluoromethyl, CF3O, nitro, oxo, amino, alkylamino wherein the alkyl group has 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, or combinations thereof and/or substituted in the alkyl portion by halogen, cyano, or methyl or combinations thereof;
• R4 is aryl having 6 to 14 carbon atoms and which is substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkenyl having 2 to 12 carbon atoms, alkynyl having 2 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, OCF3, amino, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, pyrrolyl, tetrazole-5-yl, 2(-heterocycle)tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, alkylsulfonyl having 1 to 12 carbon atoms, phenoxy, trialkylsilyloxy wherein each alkyl group has 1 to 12 carbon atoms, R5-L-, or combinations thereof;
• R5 is H,
• alkyl having 1 to 8 carbon atoms, which is unsubstituted or substituted one or more times with halogen, C1-4-alkyl, C1-4-alkoxy, oxo, or combinations thereof,
• alkylamino or dialkylamino wherein each alkyl portion has independently 1 to 8 carbon atoms,
• a partially unsaturated carbocycle-alkyl group wherein the carbocyclic portion has 5 to 14 carbon atoms and the alkyl portion has 1 to 5 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, nitro, cyano, oxo, or combinations thereof,
• cycloalkyl having 3 to 10 carbon atoms, which is unsubstituted or substituted one or more times by halogen, hydroxy, oxo, cyano, alkoxy having 1 to 12 carbon atoms, alkyl having 1 to 4 carbon atoms, or combinations thereof,
• cycloalkylalkyl having 4 to 16 carbon atoms, which is unsubstituted or substituted in the cycloalkyl portion and/or the alkyl portion one or more times by halogen, oxo, cyano, hydroxy, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms or combinations thereof,
• aryl having 6 to 14 carbon atoms and which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, amino, aminomethyl, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, alkylsulfonyl having 1 to 12 carbon atoms, phenoxy, cycloalkyl having 3 to 10 carbon atoms, aryl having 6 to 14 carbon atoms which is substituted unsubstituted, heteroaryl having one or two rings and a total number of 5 to 10 ring atoms wherein at least one of the ring atoms is a heteroatom and which is substituted unsubstituted, or combinations thereof, or
• arylalkyl having 7 to 19 carbon atoms, wherein the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, arylalkyl radical is unsubstituted or substituted, in the aryl portion, one or more times by halogen, trifluoromethyl, CF3O, nitro, amino, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, amino, alkylamino having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms and/or substituted in the alkyl portion by halogen, cyano, or methyl,
• L is a single bond or a divalent aliphatic radical having 1 to 8 carbon atoms wherein one or more —CH2— groups are each optionally replaced by —O—, —S—-NR6—, —SO2NH—, —NHSO2—, —SO2NR6—, —NR6SO2—, —CO—, —NR6CO—, —CONR6—, —NHCONH—, —OCONH, —NHCOO—, —SCONH—, —SCSNH—, or —NHCSNH—;
• and
• R6 is H,
• alkyl having 1 to 8 carbon atoms, which is branched or unbranched and which is unsubstituted or substituted one or more times with halogen, C1-4-alkyl, C1-4-alkoxy, oxo, or combinations thereof;
• arylalkyl having 7 to 19 carbon atoms, wherein the aryl portion has 6 to 14 carbon atoms and the alkyl portion, which is branched or unbranched, has 1 to 5 carbon atoms, arylalkyl radical is unsubstituted or substituted, in the aryl portion, one or more times by halogen, trifluoromethyl, CF3O, nitro, amino, alkyl having 1 to 12 carbon atoms, alkoxy having 1 to 12 carbon atoms, alkylamino having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, and/or substituted in the alkyl portion by halogen, cyano, or methyl;
• aryl having 6 to 14 carbon atoms and which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 12 carbon atoms, hydroxy, alkoxy having 1 to 12 carbon atoms, alkoxyalkoxy wherein each alkoxy group has 1 to 12 carbon atoms, nitro, methylenedioxy, ethylenedioxy, trifluoromethyl, amino, aminomethyl, aminoalkyl having 1 to 12 carbon atoms, aminoalkoxy having 1 to 12 carbon atoms, dialkylamino wherein each alkyl group has 1 to 12 carbon atoms, hydroxyalkyl having 1 to 12 carbon atoms, hydroxamic acid, tetrazole-5-yl, hydroxyalkoxy having 1 to 12 carbon atoms, carboxy, alkyl —O—CO— wherein the alkyl portion has 1 to 12 carbon atoms, cyano, alkanoyl having 1 to 13 carbon atoms, aroyl having 7 to 15 carbon atoms, alkylthio having 1 to 12 carbon atoms, alkylsulfinyl having 1 to 12 carbon atoms, or alkylsulfonyl having 1 to 12 carbon atoms;
• or a pharmaceutically acceptable salt thereof;
• with the provisos that:
• (a) R4 is at least monosubstituted by R5-L in which L is a divalent aliphatic radical having 1 to 8 carbon atoms wherein at least one —CH2— group is replaced by —SO2NR6— or —NR6SO2— in which R6 is aryl or arylalkyl which in each case is substituted or unsubstituted;
• (b) R4 is at least monosubstituted by R5-L in which L is a divalent aliphatic radical having 1 to 8 carbon atoms wherein at least one —CH2— group is replaced by —NR6—, —SO2NR6—, —NR6SO2—, —NR6CO—, or —CONR6— and R6 is aryl or arylalkyl which in each case is substituted or unsubstituted;
• (c) R4 is at least monosubstituted by R5-L in which R5 is aryl or a heterocyclic group each being substituted by cycloalkyl, aryl or heteroaryl;
• (d) R4 is at least monosubstituted by R5-L in which L is —SO—, —SO2—, —CONR6SO2—, —SO2NR6CO—, or —SO2NR6—, with the further proviso that when R4 is at least monosubstituted by R5-L in which L is —SO2NR6—, then R6 is other than H;
• or
• (e) said compound is selected from
• 3-Cyclopentyloxy-4-methoxy-N-(3-tert-butyloxycarbonylphenyl)-N-(3-pyridylmethyl))-aniline,
• N-(3,4-Bis-difluoromethoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclobutyloxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3,4-Dimethoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Ethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Isopropoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3-Cyclopropylmethoxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-4-aminobenzoic acid,
• N-(3,4-Dimethoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid,
• and pharmaceutically acceptable salts thereof.