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US 2009/0047271 A1Published application
Stable recombinant adenosine deaminase
AssigneeEnzon Pharmaceuticals, Inc.
InventorsDavid R. Filpula, Stephen K. Youngster
Life of this patent
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Abstract
A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.
Claims26
A recombinant adenosine deaminase, wherein an oxidizable amino acid residue expressed in the wild-type of the adenosine deaminase is replaced by a non-oxidizable amino acid residue.
An isolated DNA that encodes a recombinant adenosine deaminase having the amino acid sequence SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.