Treatment simulator for brain diseases and method of use thereof

A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising:

• a computer;
• and
• an application configured to operate with the computer, the application capable of:
• obtaining radiological imaging from the brain;
• obtaining anatomical information from the radiological imaging within a region of interest within the brain;
• constructing a physiological states model which assesses physiological states of the region of interest;
• locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model;
• and
• creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

A method for providing information regarding administration of a chemotherapy treatment for neurological disease in a patient, comprising:

• obtaining radiological imaging from the brain of the patient following systemic administration of an agent into the brain;
• obtaining serum concentration level information of the agent;
• determining central nervous system tissue concentration level information of the agent, the tissue concentration level information accounting for blood-brain barrier state information, chemical property information, and physical property information of the agent;
• obtaining other physiological information from radiological imaging and/or clinical data;
• displaying the radiological imaging, the serum concentration level information, the tissue concentration level information, or the other physiological information, or any combination thereof, in a chemotherapy model.

A system for providing information regarding administration of treatment for neurological disease in a patient, comprising:

• a server coupled to a network;
• a user terminal coupled to the network;
• an application coupled to the server and/or the user terminal, wherein the application is configured for:
• obtaining radiological imaging from the brain of the patient following systemic administration of an agent into the brain;
• obtaining serum concentration level information of the agent;
• determining central nervous system tissue concentration level information of the agent, the tissue concentration level information accounting for blood-brain barrier state information, chemical property information, and physical property information of the agent;
• obtaining other physiological information from radiological imaging and/or clinical data;
• displaying the radiological imaging, the serum concentration level information, the tissue concentration level information, or the other physiological information, or any combination thereof, in a chemotherapy model.

A method for providing a representation and display of brain physiological information, comprising:

• obtaining radiological imaging correlates of a physiological state of the brain;
• obtaining a constitutive property of the brain;
• constructing a network representation of the constitutive property and any corresponding flow;
• and
• displaying the network representation with the radiological imaging as a pseudo-channel model.

A system for providing a representation and display of brain physiological information, comprising:

• a server coupled to a network;
• a user terminal coupled to the network;
• an application coupled to the server and/or the user terminal, wherein the application is configured for:
• obtaining radiological imaging correlates of a physiological state of the brain;
• obtaining a constitutive property of the brain;
• constructing a network representation of the constitutive property and any corresponding flow;
• and
• displaying the network representation with the radiological imaging as a pseudo-channel model.