Absorbable / biodegradable composite yarn constructs and applicatons thereof
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, Shawn Peniston, M. Scott Taylor, Douglas D. Greene
Life of this patent
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Abstract
Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
Claims19
A warp-knitted composite mesh having a minimum area density of 50 g/m2, the mesh comprising:
- (a) a slow-absorbing, biodegradable multifilament yarn component having an individual filament diameter of less than about 20 microns, the slow-absorbing yarn component comprising a segmented copolymer comprising at least 80 percent of l-lactide-based sequences;
- and
- (b) a fast-absorbing multifilament yarn component having an individual filament diameter of greater than about 20 microns, the fast-absorbing yarn component comprising a segmented polyaxial copolymer comprising at least 70 percent of glycolide-based sequences.
A warp-knitted composite mesh having a minimum area density of 50 g/m2, the mesh comprising:
- (a) a slow-absorbing, biodegradable multifilament yarn component having an individual filament diameter of less than about 20 microns, the slow-absorbing yarn component comprising degummed silk;
- and
- (b) a fast-absorbing multifilament yarn component having an individual filament diameter of greater than about 20 microns, the fast-absorbing yarn component comprising a segmented polyaxial copolymer comprising at least 70 percent of glycolide-based sequences.
A warp-knitted composite mesh having a minimum area density of 50 g/m2, the mesh comprising:
- (a) a slow-absorbing, biodegradable multifilament yarn component having an individual filament diameter of less than about 20 microns, the slow-absorbing yarn component comprising poly-3-hydroxyalkanoate made of molecular chains of at least 50 percent of 3-hydroxybutyric acid-derived sequences;
- and
- (b) a fast-absorbing multifilament yarn component having an individual filament diameter of greater than about 20 microns, the fast-absorbing yarn component comprising a segmented polyaxial copolymer comprising at least 70 percent of glycolide-based sequences.
A braided composite suture comprising
- (a) a slow-absorbing/biodegradable multifilament yarn component having an individual filament diameter of less than about 20 micron, the slow-absorbing/biodegradable yarn component capable of retaining at least 20 percent of its initial breaking strength when tested individually as a braid and incubated in a phosphate buffer at pH 7.2 and 50° C. for about 2 weeks;
- and
- (b) a fast-absorbing/biodegradable multifilament yarn component capable of retaining at least 20 percent of its initial breaking strength when tested individually as a braid and incubated in a phosphate buffer at pH 7.2 and 50° C. for about 1 day.
Dependencies are inferred from the claim text.