Alpha-substituted vinyltin compound

An α-substituted vinyltin compound represented by the formula (1), a tautomer or salt of the compound or a solvate thereof:

• R2CH═C(R3)Sn(R1) (1)
• wherein R1 is a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom) or a C2-14 aryl group (the C2-14 group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom);
• R2 is a C2-14 aryl group, a C2-9 heterocyclyl group or a C3-10 cycloalkyl group (each of the C2-14 aryl group, C2-9 heterocyclyl group and C3-10 cycloalkyl group may optionally be substituted by a substituent represented by —W1(CW2W3)mW4 (wherein W1 is (CR5R6)n (wherein R5 and R6 are each independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or they together form O═ or S═, and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR7 (wherein R7 is a hydrogen atom, a C1-6 alkyl group, a formyl group or a C1-6 alkylcarbonyl group), W2 and W3 are each independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted by a halogen atom), m is 0, 1, 2 or 3, and W4 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a thiol group, a protected thiol group, an amino group, a protected amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C1-10 thioalkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (each of the C1-10 alkyl group, C1-10 thioalkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C2-9 heterocyclyl group, C1-10 alkoxy group, C1-10 alkylcarbonyloxy group, C1-10 alkylcarbonylamino group and mono- or di-C1-10 alkylamino group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)), a C2-14 aryl group (the C2-14 aryl group may optionally be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiol group, a protected thiol group, a phosphonic acid group, a phosphonic acid C1-6 alkyl ester group, a protected phosphonic acid group, a sulfonic acid group, a sulfonic acid C1-6 alkyl ester group, a protected sulfonic acid group, a tetrazole group, a protected tetrazole group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)), S(═O)2R8, P(═O)2R8, S(═O)R8, C(═O)R8, C(═S)R8 (wherein R8 is a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C2-9 heterocyclyl group, a C1-10 alkoxy group (each of the C1-10 alkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C2-9 heterocyclyl group and C1-10 alkoxy group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)), a C2-14 aryl group, a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may optionally be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or NR9R10 (wherein R9 and R10 are each independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylsulfonyl group, a C1-10 alkylcarbonyl group (each of the C1-10 alkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C1-10 alkoxy group, C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, C1-10 alkylsulfonyl group and C1-10 alkylcarbonyl group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or a C2-14 aryl group (the C2-14 aryl group may optionally be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)), or R9 and R10 together form —(CH2)m1-G-(CH2)m2— (wherein G is an oxygen atom, a sulfur atom, CR11R12 (wherein R11 and R12 are each independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR13 (wherein R13 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylsulfonyl group, a C1-10 alkylcarbonyl group (each of the C1-10 alkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C1-10 alkoxy group, C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, C1-10 alkylsulfonyl group and C1-10 alkylcarbonyl group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or a C2-14 aryl group (the C2-14 aryl group may optionally be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom))), and m1 and m2 are each independently an integer of from 0 to 5, provided that m1+m2 is 3, 4 or 5))), a tetrazole group or a protected tetrazole group));
• and
• R3 is a carbamoyl group, a thiocarbamoyl group, an isonitrile group, an isocyanate group, an isothiocyanate group, a formylamino group, a thioformylamino group, or —NH(C═X)R4 (wherein X is an oxygen atom or a sulfur atom, R4 is a C1-10 thioalkyl group, a C1-10 alkoxy group (each of the C1-10 thioalkyl group and C1-10 alkoxy group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or NR14R15 (wherein R14 and R15 are each independently a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylsulfonyl group, a C1-10 alkylcarbonyl group (each of the C1-10 alkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C1-10 alkoxy group, C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, C1-10 alkylsulfonyl group and C1-10 alkylcarbonyl group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or a C2-14 aryl group (the C2-14 aryl group may be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)), or R14 and R15 together form —(CH2)m3-J-(CH2)m4— (wherein J is an oxygen atom, a sulfur atom, CR16R17 (wherein R16 and R17 are each independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR18 (wherein R18 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylsulfonyl group, a C1-10 alkylcarbonyl group (each of the C1-10 alkyl group, C2-10 alkenyl group, C2-6 alkynyl group, C1-10 alkoxy group, C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, C1-10 alkylsulfonyl group and C1-10 alkylcarbonyl group may optionally be substituted by a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom)) or a C2-14 aryl group (the C2-14 aryl group may optionally be substituted by a C1-10 alkyl group (the C1-10 alkyl group may be substituted by a halogen atom), a C2-10 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a protected amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group or a C2-14 aryloxy group (each of the C2-14 aryl group and C2-14 aryloxy group may be substituted by a C1-6 alkyl group (the C1-6 alkyl group may be substituted by a halogen atom) or a halogen atom))), and m3 and m4 are each independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))).