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US 2009/0023900 A1Published application
Anti-AlphaVBeta3 Recombinant Human Antibodies, Nucleic Acids Encoding Same
AssigneeApplied Molecular Evolution, Inc.
InventorsWilliam D. Huse, Herren Wu
Life of this patent
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Abstract
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αvβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αvβ3 by contacting αvβ3 with an enhanced LM609 grafted antibody.
Claims2
An enhanced LM609 grafted antibody exhibiting selective binding affinity to ÿVÿ3, or a functional fragment thereof, comprising a CDR selected from the group consisting of a VH CDR2 referenced as SEQ ID NO:104;
- a VH CDR3 referenced as SEQ ID NO:106;
- and a VL CDR1 referenced as SEQ ID NO:110.
2-86. (canceled)
Dependencies are inferred from the claim text.