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US 2009/0023890 A1Published application
Membrane Active Heteropolymers
AssigneeRoche Madison Inc.
InventorsSean D. Monahan, Darren H. Wakefield, David B. Rozema, Lori Higgs, Jon A. Wolff, James E. Hagstrom
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Abstract
The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
Claims23
A membrane active heteropolymer comprising:
- a plurality of amine-containing monomers, a plurality of first hydrophobic monomers, and a plurality of second hydrophobic monomers wherein said first and second hydrophobic monomers each contain pendent groups having 1-30 carbon atoms, wherein said first and second hydrophobic monomers are different and wherein the ratio of amine-containing monomers to first hydrophobic monomers to second hydrophobic monomers is about 6:3:1.
Dependencies are inferred from the claim text.