Production and Purification of Esters of Polyunsaturated Fatty Acids
AssigneeMartek Biosciences Corporation
InventorsKrishna Raman, Jung Lee, Neil Leininger, Chris Luigart
Life of this patent
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Abstract
The present invention includes methods for producing and purifying esters of polyunsaturated fatty acids that include reacting a composition having triglycerides with polyunsaturated fatty acid residues in the presence of an alcohol and a base to produce an ester of a polyunsaturated fatty acid from the triglycerides. The composition can be a polyunsaturated fatty acid-containing composition that has not been conventionally processed. The reacted composition can be further processed by distillation.
Claims72
A method for purifying a composition comprising triglycerides having polyunsaturated fatty acid residues comprising:
- a) reacting the composition in the presence of an alcohol and a base to produce an ester of a polyunsaturated fatty acid from the triglycerides;
- and
- b) distilling the composition to recover a fraction comprising the ester of the polyunsaturated fatty acid.
A method for producing an ester of a polyunsaturated fatty acid from a composition comprising triglycerides having polyunsaturated fatty acid residues comprising:
- a) transesterifying the composition in the presence of an alcohol and a base to produce an ester of the polyunsaturated fatty acid from the triglycerides;
- and
- b) distilling the composition to recover a fraction comprising the ester of the polyunsaturated fatty acid.
(canceled)
A method for preparing a composition comprising an ester of a polyunsaturated fatty acid comprising:
- reacting a composition comprising triglycerides having polyunsaturated fatty acid residues in the presence of an alcohol and a base to produce an ester of a polyunsaturated fatty acid from the triglycerides,
- wherein the composition comprising triglycerides having polyunsaturated fatty acid residues has not been subjected to one or more treatments selected from the group consisting of refining, desolventization, deodorization, winterization, chill filtration, and bleaching.
40-67. (canceled)
A composition comprising at least about 90 wt. % ethyl ester of docosahexaenoic acid, wherein the composition further comprises at least about 0.1 wt. % of 4,7,10,13,16,19,22,25 octacosaoctaenoic acid (C28:8) or an ester thereof.
A composition comprising at least about 90 wt. % ethyl ester of docosahexaenoic acid, wherein the composition further comprises at least about 0.1 wt. % of docosapentaenoic acid (n-3) or an ester thereof.
A composition comprising at least about 90 wt. % ethyl ester of docosahexaenoic acid, wherein the composition further comprises at least one additional fatty acid or an ester thereof with a boiling point of about 150-170° C. at a pressure of 0.8 mm Hg.
95-98. (canceled)
A composition comprising at least about 90 wt. % of a combination of ethyl ester of docosahexaenoic acid and ethyl ester of docosapentaenoic acid (n-6).
100-109. (canceled)
Dependencies are inferred from the claim text.