Composition Containing Anti-Dementia Drug

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a dissolution ratio for each of the donepezil hydrochloride and the memantine hydrochloride in a dissolution test solution of pH 6 to 8 is less than 60% at a dissolution time of 1 hour, and is not less than 80% at a dissolution time of 8 hours.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a dissolution ratio for the donepezil hydrochloride in a dissolution test solution of pH 1 to 2 is at least 60% at a dissolution time of 1 hour, and a dissolution ratio for the memantine hydrochloride in a dissolution test solution of pH 6 to 8 is less than 60% at a dissolution time of 1 hour and is not less than 80% at a dissolution time of 8 hours.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a dissolution ratio for the memantine hydrochloride in a dissolution test solution of pH 1 to 2 is at least 60% at a dissolution time of 1 hour, and a dissolution ratio for the donepezil hydrochloride in a dissolution test solution of pH 6 to 8 is less than 60% at a dissolution time of 1 hour and is not less than 80% at a dissolution time of 8 hours.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a dissolution ratio for each of the donepezil hydrochloride and the memantine hydrochloride in a dissolution test solution of pH 1 to 2 is not less than 60% at a dissolution time of 1 hour.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a proportion of a dissolution ratio for the memantine hydrochloride to a dissolution ratio for the donepezil hydrochloride is in a range of 1±0.3 at least three dissolution time points.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a f2 function value for dissolution profiles for the donepezil hydrochloride and the memantine hydrochloride is in a range of 42 to 100.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, for dissolution times of 2 hours onwards, a proportion of a dissolution ratio in a dissolution test solution of pH 1 to 2 to the dissolution ratio in a dissolution test solution of pH 6 to 8 for the donepezil hydrochloride is in a range of 1±0.3, and a proportion of a dissolution ratio in a dissolution test solution of pH 1 to 2 to a dissolution ratio in a dissolution test solution of pH 6 to 8 for the memantine hydrochloride is in a range of 1±0.3.

A composition comprising:

• donepezil hydrochloride;
• and
• memantine hydrochloride,
• wherein under a Japanese Pharmacopoeia paddle dissolution test method, a f2 function value for dissolution profiles in a dissolution test solution of pH 1 to 2 and a dissolution test solution of pH 6 to 8 for the donepezil hydrochloride is in a range of 42 to 100, and a f2 function value for dissolution profiles in a dissolution test solution of pH 1 to 2 and a dissolution test solution of pH 6 to 8 for the memantine hydrochloride is in a range of 42 to 100.