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US 2009/0023772 A1Published application
Novel substituted heteroaryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors
OwnerBirgitte L. Eriksen, Dan Peters +3inventors
InventorsBirgitte L. Eriksen, Dan Peters, Elsebet Ostergaard Nielsen, Jorgen Scheel-Kruger, Gunnar M. Olsen
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Abstract
This invention relates to novel substituted heteroaryloxy alkylamines useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims12
A compound of Formula I:
- any of its isomers or any mixture of its isomers,
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 represents a quinolyl, isoquinolyl or pyridyl group;
- which group is optionally substituted with one or more substituents independently selected from the group consisting of:
- halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl;
- n is 1 or 2;
- R2 and R3 independent of each other represent hydrogen or alkyl;
- the bond . . . represents a single or a double bond;
- R4 and R5 independent of each other represent hydrogen or alkyl;
- or R4 and R5 together with the carbon atoms to which they are attached form a three-membered carbocyclic ring;
- and
- R6 represents hydrogen or alkyl.
10 more elements
(canceled)
Dependencies are inferred from the claim text.