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US 2009/0023767 A1Published application
Inhibitors of Checkpoint Kinases
AssigneeMerck & Co., Inc.
InventorsEdward J. Brnardic, Mark E. Fraley
Life of this patent
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Abstract
The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
Claims6
A compound of the Formula A:
- wherein:
- R1 is independently selected from H and F, wherein at least one of R1 is F;
- or a pharmaceutically acceptable salt or a stereoisomer thereof.
Dependencies are inferred from the claim text.