Pharmaceutical formulation of apomorphine for buccal administration
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorAnthony Clarke
Life of this patent
Estimating the term…
Abstract
The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function.
Claims20
A kit comprising a container, which comprises separate first and second compartments, wherein the first compartment comprises the following components (a):
- (a) a combination of:
- (i) apomorphine or a pharmaceutically acceptable acid addition salt thereof, and
- (ii) a pharmaceutically acceptable excipient or carrier;
- and wherein the second compartment comprises the following component (b):
- (b) a solution which comprises a diluent and a pH modifying agent;
- wherein the first and second compartments are arranged such that components (a) and (b) can be combined at the point of use of the kit to produce a formulation having a pH ranging from mildly acidic to alkaline, and which is suitable for buccal administration.
A process for producing a pharmaceutical composition, which process comprises combining apomorphine or a pharmaceutically acceptable acid addition salt thereof with a solution which comprises a diluent and a pH modifying agent, such that the resulting formulation is has a pH ranging from mildly acidic to alkaline, and is suitable for buccal administration.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of administering an apomorphine composition to a patient in need thereof, comprising:
- (a) optionally adjusting the pH of a composition comprising a pharmaceutically effective amount of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier to a pH ranging from mildly acidic to alkaline;
- and
- (b) delivering the composition buccally to a patient in need thereof.
Dependencies are inferred from the claim text.