Compounds that protect against sensory hair cell death
AssigneesUniversity of Washington, Fred Hutchinson Cancer Research Center
InventorsHenry C. Ou, Felipe Santos, Edwin W. Rubel, David W. Raible, Julian A. Simon
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Abstract
The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.
Claims20
A method of preventing a condition associated with sensory hair cell death, the method comprising administering a sufficient amount of a compound comprising a thiophene-carboxamide moiety of Formula I or Formula II, wherein said compound inhibits lateral line hair cell death in a zebrafish.
A method of inhibiting sensory hair cell death, the method comprising administering a sufficient amount of a compound comprising a thiophene-carboxamide moiety of Formula I or Formula II, wherein said compound inhibits lateral line hair cell death in a zebrafish.
A method of preventing a condition associated with sensory hair cell death, the method comprising administering a sufficient amount of a compound selected from the group consisting of:
- cepharanthine, amsacrine, drofenine, phenoxybenzamine, N,N-hexamethyleneamiloride, carvedilol and 9-amino-1,2,3,4-tetrahydroacridine.
Dependencies are inferred from the claim text.