Aryl/hetarylamides as modulators of the ep2 receptor

A method of using a compound of the formula I

• in which
• A is an aryl or heteroaryl radical which may optionally be substituted one or more times by R3 and/or R4,
• R1 is a hydrogen, a C1-C6-alkyl radical which may optionally be substituted,
• R2 is a hydrogen, halogen, cyano, an —S(O)q—CH3, where q is 0-2, a C1-C4-alkoxy radical or C1-C6-alkyl, where this radical can be substituted in any way,
• R3 is a hydrogen, halogen, amino, an —S(O)p—C1-C6-alkyl group, where p is 0-2,
• a C1-C6-acyl, NH—CO—NH2, —O—CO—NH(C1-C6-alkyl), —O—CO—N(C1-C6-alkyl)2 or NH—CO—C1-C6-alkyl radical,
• a C1-C6-alkyl which may optionally be substituted one or more times, identically or differently, by C1-C6-acyl, C1-C6-alkoxy, hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, C5-C12-heteroaryl, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or by CO—N(C1-C6-alkyl)2,
• a C1-C6-alkoxy which may optionally be substituted one or more times, identically or differently, by hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, NH—C3-C6-cycloalkyl, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or by CO—N(C1-C6-alkyl)2,
• an O—C6-C12-aryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• a CH2O—C6-C12-aryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• an O—C5-C16-heteroaryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• a hydroxy, cyano, O—CO—(C1-C6-alkyl), CO—NH(C5-C12-heteroaryl), NH—(C1-C6-alkyl), N—(C1-C6-alkyl)2,
• a C6-C12-aryl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-acyl, C1-C6-alkoxy, C6-C12-aryl, C5-C12-heteroaryl, hydroxy, CH2—OH, cyano, CH2—CN, amino, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, NHSO2CH3, SO2NH2, SO2NH(C1-C6-alkyl), SO2N(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl), CO—N(C1-C6-alkyl)2, CO—NH(C5-C12-heteroaryl), NH—CO(C1-C6-alkyl), CH2—NH—CO(C1-C6-alkyl), NH—CO(C5-C12-heteroaryl), CH2—NH—CO(C5-C12-heteroaryl), styryl, or an —S(O)r—CH3, where r is 0-2, or two adjacent positions may be substituted by —O—CH2—O— or —O—C(CH3)2—O—,
• a monocyclic C5-C7-heteroaryl which may optionally be substituted one or more times, identically or differently, by C1-C6-alkyl, if R2 is cyano or if R1 and/or R2 is identically or differently a C1-C6-alkyl radical, where at least one of the radicals is substituted at least once, or if R4 is —S(O)p—C1-C6-alkyl, where p is 0-2, C1-C6-acyl-, —O—CO—NH(C1-C6-alkyl), —O—CO—N(C1-C6-alkyl)2, C6-C12-aryloxy, C5-C16-heteroaryloxy, hydroxy, cyano or N—(C1-C6-alkyl)2,
• a monocyclic C5-C7-heteroaryl which may be substituted at least one or more times, identically or differently, by halogen, CF3, C1-C6-acyl, C1-C6-alkoxy, hydroxy, CH2—OH, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or CO—N(C1-C6-alkyl)2,
• a bi- or tricyclic C8-C12-heteroaryl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, C1-C6-acyl, C1-C6-alkoxy, hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or CO—N(C1-C6-alkyl)2, or
• a C3-C6-cycloalkyl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, hydroxy, cyano, CO2—(C1-C6-alkyl), C1-C6-acyl, N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl), CO—N(C1-C6-alkyl)2 or C1-C6-alkoxy,
• R4 is a hydrogen, halogen, amino, —S(O)p—C1-C6-alkyl, where p is 0-2,
• a C1-C6-acyl, NH—CO—NH2, NH—CO—C1-C6-alkyl, —O—CO—NH(C1-C6-alkyl), —O—CO—N(C1-C6-alkyl)2 or C1-C6-alkyl group which may optionally be substituted one or more times, identically or differently, by C1-C6-acyl, C1-C6-alkoxy, hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, C5-C12-heteroaryl, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or by CO—N(C1-C6-alkyl)2,
• a C1-C6-alkoxy which may optionally be substituted one or more times, identically or differently, by hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, NH—C3-C6-cycloalkyl, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or by CO—N(C1-C6-alkyl)2, an O—C6-C12-aryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• a CH2O—C6-C12-aryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• an O—C5-C16-heteroaryl which may optionally be substituted by hydroxy, cyano, COOH or CO—NH2,
• a hydroxy, cyano, O—CO—(C1-C6-alkyl), CO—NH(C5-C12-heteroaryl), NH—(C1-C6-alkyl), N—(C1-C6-alkyl)2,
• a C6-C12-aryl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-acyl, C1-C6-alkoxy, C6-C12-aryl, C5-C12-heteroaryl, hydroxy, CH2—OH, cyano, CH2—CN, amino, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, NHSO2CH3, SO2NH2, SO2NH(C1-C6-alkyl), SO2N(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl), CO—N(C1-C6-alkyl)2, CO—NH(C5-C12-heteroaryl), NH—CO(C1-C6-alkyl), CH2—NH—CO(C1-C6-alkyl), NH—CO(C5-C12-heteroaryl), CH2—NH—CO(C5-C12-heteroaryl), styryl, or an —S(O)r—CH3, where r is 0-2, or two adjacent positions may be substituted by —O—CH2—O— or —O—C(CH3)2—O—,
• a monocyclic C5-C7-heteroaryl which may optionally be substituted one or more times, identically or differently, by C1-C6-alkyl, if R2 is cyano or if R1 and/or R2 is identically or differently a C1-C6-alkyl radical, where at least one of the radicals is substituted at least once,
• a monocyclic C5-C7-heteroaryl which may be substituted at least one or more times, identically or differently, by halogen, CF3, C1-C6-acyl, C1-C6-alkoxy, hydroxy, CH2—OH, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or CO—N(C1-C6-alkyl)2,
• a bi- or tricyclic C8-C12-heteroaryl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, C1-C6-acyl, C1-C6-alkoxy, hydroxy, cyano, CO2—(C1-C6-alkyl), N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl) or CO—N(C1-C6-alkyl)2, or
• a C3-C6-cycloalkyl which may optionally be substituted one or more times, identically or differently, by halogen, by C1-C6-alkyl, hydroxy, cyano, CO2—(C1-C6-alkyl), C1-C6-acyl, N—(C1-C6-alkyl)2, COOH, CO—NH2, CO—NH(C1-C6-alkyl), CO—N(C1-C6-alkyl)2 or C1-C6-alkoxy,
• R3 and R4 are either in ortho, meta position or meta, para position relative to one another and together have the meaning —O—CO—S—, —S—CO—O—, CH2—CO—O—, O—CO—CH2—, —CH2—CO—NH—, —NH—CO—CH2—, —O—CO—NH—, —NH—CO—O—, —CO—CH2—(CH2)m—, —CH2—(CH2)m—CO—, —O—(CH2)m—O—, —O—C—(CH3)2—O—, —CH2—(CH2)m—CH2—, where m is 1-3,
• Y is a —(CH2)n— group, where n is 1-3,
• and the isomers, diastereomers, enantiomers and salts thereof, and cyclodextrin clathrates, where the following compounds are excluded:
• N-[2-(7-fluoro-2,4-dimethyl-1H-indol-3-yl)ethyl]-3,4-dimethoxybenzamide
• N-[2-(7-fluoro-2,4-dimethyl-1H-indol-3-yl)ethyl]-2-methylbenzamide
• 4-bromo-N-[2-(7-fluoro-2,4-dimethyl-1H-indol-3-yl)ethyl]benzamide.