Diaminopyrimidines as modulators of the ep2 receptor

A compound of the formula I

• where
• Y is a CH group or a C(C1-C4-alkyl) group,
• V is a hydrogen, a C1-C4-alkyl group,
• n is 0, 1 or 2,
• W is a 6-10-membered, mono- or bicyclic aryl ring which is in each case unsubstituted or optionally substituted once to three times,
• a 5-10-membered, mono- or bicyclic heteroaryl ring which is in each case unsubstituted or optionally substituted once to three times,
• an 8-12-membered aryl- or heteroaryl-cycloalkyl or -cycloalkenyl group which is in each case unsubstituted or optionally substituted once to three times,
• an 8-12-membered aryl- or heteroaryl-heterocyclyl or -heterocyclenyl group which is in each case unsubstituted or optionally substituted once to three times,
• a 3-12-membered, mono-, bi- or tricyclic cycloalkyl radical which is in each case unsubstituted or optionally substituted once, where the substituents are linked either directly or via a spacer U to W and may be selected from the group of halogen, cyano, R4, OR4, OC(O)R4, S(O)nR4, where n is 0, 1, 2, SO2NR4R5, SO2NR5C(O)R4, NR4R5, NR5C(O)R4, NR5SO2R4, C(O)NR5SO2R4, C(OH)R4R5, C(O)R4, C(NOH)R4, CO2R4,C(O)NR4R5,
• or
• in the case where n=0 together with V is a pyrrolidine, piperidine, morpholine or thiomorpholine residue which is in each case unsubstituted or optionally substituted once,
• or else
• in the case where n=0 together with V is a piperazine residue, which is unsubstituted or optionally N-substituted, where the substituents are linked either directly or via a spacer U to W and may be selected from the group of halogen, cyano, R4, OR4, OC(O)R4, S(O)NR4 where n is 0, 1, 2, SO2NR4R5, SO2NR5C(O)R4, NR4R5, NR5C(O)R4, NR5SO2R4, C(O)NR5SO2R4, C(OH)R4R5, C(O)R4, C(NOH)R4, CO2R4, C(O)NR4R5,
• U is a C1-C4-alkylene, C2-C4-alkenylidene, C2-C4-alkynylidene, O—C1-C4-alkylene, C(O)—C1-C4-alkylene, S(O)n—C1-C4-alkylene, where n is 0, 1, 2, N(R5)—C1-C4-alkylene, C(O)—N(R5)—C1-C4-alkylene, N(R5)—C(O)—C1-C4-alkylene spacer,
• R1 is a C1-C4-alkyl group or cyano,
• R2 is a hydrogen, halogen, cyano, a C1-C4-alkyl group,
• R3 is a hydrogen, halogen, cyano, a C1-C4-alkyl group,
• R4 is a hydrogen, a C1-C4-alkyl group, a C2-C4-alkenyl group, a C2-C4-alkynyl group, a C3-C6-cycloalkyl group, a CH2—C3-C6-cycloalkyl group, a 6-membered aryl ring, a 5-6-membered heteroaryl ring or a CH2-aryl or heteroaryl group, where the aryl radical is 6-membered and the heteroaryl radical is 5 or 6-membered,
• R5 is a hydrogen, a C1-C4-alkyl group and
• R4, R5 together form a 3-6-membered cycloalkyl or a heteroatom-containing ring,
• and the isomers, diastereomers, enantiomers and salts thereof, and cyclodextrin clathrates.