Sulphonamide Derivatives

A sulphonamide derivative of formula (I) or a physiologically acceptable salt thereof,

• where
• RC is selected from a group consisting of dialkylamino, NO2, CN, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkanoyl, oxazol-2-yl, oxazolylaminocarbonyl, aryl, aroyl, aryl-CH(OH)—, arylaminocarbonyl, furanyl, where the aryl, aroyl and furanyl moieties may be substituted, guanidinyl-(CH2)z—N(R′)—, Het-(CH2)z—N(R′)—, Het-CO—N(R′)—, Het-CH(OH)— and Het-CO—, where Het is an optionally substituted 46-membered heterocyclic ring containing one or more heteroatoms selected from N, S and O, R′ is hydrogen or alkyl, and z is an integer 1 to 5;
• RA is a group having the formula
• wherein
• R3 and R4 represent each independently hydrogen, halogen, aryl, alkoxy, carboxy, hydroxy, alkoxyalkyl, alkoxycarbonyl, cyano, trifluoromethyl, alkanoyl, alkanoylamino, trifluoromethoxy, an optionally substituted aryl or heterocyclic group, and
• RB is hydrogen, alkyl, alkanoyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminoalkyl, mono- or dialkylaminoalkyl or Het-alkyl, where Het is as defined above;
• provided that
• (i) when RC is dialkylamino, then RB is not hydrogen or alkyl;
• (ii) when RA is a group of formula (C), where R3 is hydrogen and R4 is methoxy, then RC is not Het-CO—N(R′)—;
• and
• (iii) when RA is a group of formula (C), where R3 and R4 are hydrogen or halogen, then RC is not nitro.