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US 2009/0023734 A1Published application
Inhibitors of histone deacetylase
AssigneeMethylGene Inc.
InventorsStephane Raeppel, Frederic Gaudette, Isabelle Paquin, Arkadii Vaisburg, Daniel Delorme
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Abstract
The invention provides compounds and methods for treating cell proliferative diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, excipient, or diluent, and methods of using the compounds to inhibit cellular proliferation in vitro and therapeutically.
Claims19
A compound of the following formula:
- or pharmaceutically acceptable salt thereof, wherein
- Ar is aryl or heteroaryl, each of which is optionally substituted with from 1 to 3 substituents.
A compound of the following formula:
- or pharmaceutically acceptable salt thereof, wherein
- X is —N(R1)—, —O—, or —S—;
- or X is a nitrogen-containing heterocyclyl in which a nitrogen is covalently bound to the adjacent carbonyl in structure V and is optionally substituted with from 1 to 3 substituents;
- and
- R and R1 independently are —H, or optionally substituted a) C1-C6-hydrocarbyl or b) R2-L-, wherein R2 is aryl or heteroaryl, L is C0-C6-hydrocarbyl-L1-C0-C6-hydrocarbyl, and L1 is a covalent bond, —O—, —S—, or —NH—.
2 more elements
A compound of formula:
- or a pharmaceutically acceptable salt thereof, wherein Ar1 is aryl or heteroaryl optionally substituted with from 1-3 substituents independently selected from —NO2, CH3O—, and morpholinyl (e.g., morpholin-4-yl).
Dependencies are inferred from the claim text.