Methods for the preparation and use of ferric pyrophosphate citrate chelate compositions
AssigneeRockwell Medical Technologies, Inc.
InventorWilliam S. McCall, JR.
Life of this patent
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Abstract
A highly water soluble ferric pyrophosphate citrate chelate useful for treating iron deficiency contains 2% or less phosphate by weight. These chelate compositions are easily milled and/or processed into dosage forms using conventional techniques, and are expected to exhibit advantageous biocompatibility as compared to conventional soluble ferric pyrophosphates, ferric salts, ferric polysaccharide complexes and ferrous salts.
Claims23
A water-soluble solid ferric pyrophosphate citrate chelate composition comprising:
- iron citrate pyrophosphate;
- and
- phosphate in an amount of 2% or less by weight.
A process for preparing a water-soluble solid ferric pyrophosphate citrate chelate composition comprising:
- combining a citrate ion source, a pyrophosphate ion source, and a ferric ion source in water to form a solution;
- adding an organic solvent in a volume sufficient to precipitate a solid ferric pyrophosphate citrate chelate composition from the resulting solution;
- and
- isolating the solid ferric pyrophosphate citrate chelate composition, said chelate composition having 2% or less phosphate by weight.
A pharmaceutical composition comprising:
- an oral or parenteral dosage form containing a therapeutically effective amount of a solid ferric pyrophosphate citrate chelate composition having 2% or less phosphate by weight.
A process for treating iron deficiency comprising:
- administering to a subject in need of treatment for iron deficiency, a pharmaceutical composition comprising an oral or parenteral dosage from containing a therapeutically effective amount of a solid ferric pyrophosphate citrate chelate composition having 2% or less phosphate by weight.
Dependencies are inferred from the claim text.