Complexes comprising zoledronic acid and cyclodextrins
OwnerChandrasekhar Kocherlakota, Paul Sudhakar Mogadati +1inventors
InventorsChandrasekhar Kocherlakota, Paul Sudhakar Mogadati, Sarveswara Rao Mandavilli
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Abstract
The present invention relates to stable compositions comprising zoledronic acid, wherein zoledronic acid is complexed with a cyclodextrin, such as hydroxypropyl-β-cyclodextrin. The invention further relates to processes for making the compositions.
Claims18
A complex comprising zoledronic acid and a cyclodextrin.
A pharmaceutical formulation comprising zoledronic acid and a cyclodextrin.
A pharmaceutical formulation comprising a lyophilized powder containing a complex of zoledronic acid and a hydroxypropyl-β-cyclodextrin, wherein the complex has a molar ratio of zoledronic acid to hydroxypropyl-β-cyclodextrin about 1:0.1 to about 1:2.
Dependencies are inferred from the claim text.