Amino Acid Vitamin Ester Compositions for Controlled Delivery of Pharmaceutically Active Compounds
AssigneeIDEXX Laboratories, Inc.
InventorsYerramilli V.S.N. Murthy, Michael Atkinson
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Abstract
The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
Claims55
A pharmaceutical composition comprising:
- (i) an amino acid-vitamin ester,
- (ii) an acidic pharmaceutically active compound, and
- (iii) a pharmaceutically acceptable organic solvent, wherein the pharmaceutical composition is injectable and forms a precipitate when injected into water.
A pharmaceutical composition comprising:
- (i) an amino acid-vitamin ester,
- (ii) a carboxylic acid,
- (iii) a pharmaceutically active compound selected from the group consisting of a neutral non-acidic pharmaceutically active compound and a pharmaceutically acceptable salt of a pharmaceutically active compound, and
- (iv) a pharmaceutically acceptable organic solvent,
- wherein the pharmaceutical composition is injectable and forms a precipitate when injected into water.
A pharmaceutical composition comprising:
- (i) a protonated oligonucleotide,
- (ii) an amino acid-vitamin ester, and
- (iii) a pharmaceutically acceptable organic solvent,
- wherein the pharmaceutical composition is injectable and forms a precipitate when injected into water.
Dependencies are inferred from the claim text.