snRNA gene-like transcriptional units and uses thereof
AssigneeUniversita' Degli Studi Di Genova
InventorAldo Pagano
Life of this patent
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Abstract
By a computer search for upstream promoter elements (DSE, PSE) typical of small nuclear RNA (snRNA) genes, we have identified a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene regulation network where part of the Pol III transcriptome could control its Pol II counterpart.
Claims15
1-21. (canceled)
Nucleic acid molecule comprising a nucleotide sequence that is characterized by:
- being transcribed by an RNA polymerase III,
- it does not undergone any polyadenylated tail addition (as for Pol II transcribed genes) and,
- it is able to modulate the expression of one or more specific RNA polymerase II-transcribed target genes.
A nucleic acid sequence being able to modulate the RNA polymerase III mediated expression of a nucleic acid according to claim 1, wherein the nucleic acid sequence is comprised in the bold regions of sequences from SEQ ID No. 51 to SEQ ID No. 84.
Dependencies are inferred from the claim text.